What Are Melatonin Side Effects
Melatonin needs vary from person to person. On average, most people need less than 3 milligrams per night to sleep better. Yet some people take more.
Melatonin is generally safe, but some people are more sensitive to the oral hormone and experience side effects with use. Adverse effects tend to occur with long-term use or when a person takes too much.
Possible side effects of oral melatonin include:
If you experience side effects of oral melatonin, reduce your dosage to see if symptoms improve. Everyones body is different. So while one person may be able to tolerate 3 mg a night, another person may be able to tolerate only 1 mg.
Two Common Classes Of Drugs Have Been Linked To Dementia Fortunately There Are Alternatives To Both
If you’re worried about developing dementia, you’ve probably memorized the list of things you should do to minimize your riskeating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. In addition, some of the drugs you may be taking to help you accomplish those things could increase your risk of dementia. In two separate large population studies, both benzodiazepines and anticholinergics were associated with an increased risk of dementia in people who used them for longer than a few months. In both cases, the effect increased with the dose of the drug and the duration of use.
These findings didn’t come entirely as a surprise to doctors who treat older people. The Beer’s List published by the American Geriatrics Society has long recognized benzodiazepines, antihistamines, and tricyclic antidepressants as potentially inappropriate for older adults, given their side effects. Such drugs are on the list because they share troubling side effectsconfusion, clouded thinking, and memory lapsesthat can lead to falls, fractures, and auto accidents.
Where To Learn About Other Drugs That Affect Brain Function
Many other drugs that affect brain function, but they are either not used as often as the ones above, or seem to affect a minority of older adults.
Notably, there has been a lot of concern in the media about statins, but a meta-analysis published in 2015 could not confirm an association between statin use and increased cognitive impairment. In fact, a 2016 study found that statin use was associated with a lower risk of developing Alzheimers disease.
This is not to say that statins arent overprescribed or riskier than we used to think. And its also quite possible that some people do have their thinking affected by statins. But if you are trying to eliminate medications that dampen brain function, I would recommend you focus on the ones I listed above first.
For a comprehensive list of medications identified as risky by the experts at the American Geriatrics Society, be sure to review the 2019 Beers Criteria.
You can also learn more about medications that increase fall risk in this article: 10 Types of Medications to Review if Youre Concerned About Falling.
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What To Do If You Suspect Your Medications Are Causing Insomnia
First things first: never stop taking a medication without first asking the prescribing physician about doing so. Some medications cannot be stopped without tapering off safely, and you could do more harm than good.
Doctors generally have a list of medications they routinely prescribe for certain conditions which includes alternatives for those who do not respond to their first choices.
It should not be a problem to tell your doctor you suspect your medication is keeping you awake at night and ask for an alternative prescription.
When you receive new medications, make sure you read all the labels and packaging information provided to you by the pharmacy. You can also take labeled medications to your local pharmacist to ask them if insomnia or fragmented sleep is a common side effect.
The United States Food and Drug Administration also curates a drug website you can search for information about any given prescription . If you believe you are experiencing sleep problems previously documented as side effects fora medication youre taking, you can also report your experience at their MedWatch drug safety database.
AARP Mayo Clinic
Is It Safe To Take Melotonin And Allegra D Together
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Side Effects Of Melatonin: 8 Groups Should Avoid Taking Melatonin
September 28, 2020// by Terry Cralle//
Melatonin, also known as the hormone of darkness is a hormone responsible for the regulation of your sleep-wake cycle. However, promoting and regulating sleep is only one of its physiological functions.
This hormone plays an important role in bodily functions, the functions of organs like the kidney or liver, and helps regulate blood pressure and cardiovascular issues. Melatonin is also shown useful in cases of tumors and cancers, where it prevents oxidative stress to promote the growth of cancerous cells.
Now, all of this sounds rather impressive, and sure enough, because melatonin is a naturally produced hormone coming from the very brain, no one would suspect it harmful. However, melatonin supplements, on the other hand, are raising some eyebrows in the medical community.
Over the past few years, melatonin supplements have been studied concerning their possible side effects. Turns out, melatonin intake can cause a dozen of adverse effects, which can pose a long-term danger. In the following paragraphs, well take a look at the major side effects, every melatonin producing company would hide from you. So, lets get started!
What Are Ways To Fall Asleep Naturally
A range of practices can help encourage sleep naturally, including:
- Regular exercise: People can engage in physical activity several hours before bedtime to encourage sleep.
- Avoiding stimulants: Avoid caffeine, nicotine, and alcohol for several hours before bedtime.
- Sleep schedule: Maintain the same sleep schedule where possible, even on days off, going to sleep and waking up at the same time.
- Sleep environment: Keep the bedroom dark, quiet, and slightly cool to encourage comfortable sleep.
- Avoid screens: People should stop using screens, such as smartphones, TVs, and personal devices, at least 1 hour before bed.
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Medications With The Same Active Ingredient
If you start taking a new medication that has the same active ingredient as another medication you are taking, there is a risk of an overdose of that particular ingredient. If you experience symptoms of an overdose such as seizures, vomiting, or confusion, call 911 or seek emergency medical attention.
Zarbee’s Nighttime Cough Syrup
Zarbee’s Nighttime Cough Syrup contains the following ingredients:
- Dark honey
- Grapefruit seed extract
Below is an image of the ‘Supplement Facts’ label:
Dark honey is very similar to ‘regular’ honey but is thought to contain more vitamins, minerals, and antioxidants. It’s included in this product to help reduce the frequency and severity of coughing. It can reduce throat irritation as well.
Several studies support the fact that honey can help with coughing in children, and, it appears to be just as effective as the over-the-counter cough suppressant, dextromethorphan.
Zarbee’s Nighttime Cough Syrup also contains melatonin, a hormone that humans naturally produce. Melatonin plays an important role in our sleep/wake cycle and is very commonly included in over-the-counter sleep aids as a natural alternative to other drugs, like Benadryl.
Finally, Zarbee’s Nighttime Cough Syrup includes grape seed extract. It has a variety of uses and is generally thought to help increase the absorption of various vitamins and minerals.
Adverse Effects Of Melatonin Intake: Overview
Consumption of food supplements that contain melatonin or mainly contain melatonin has shown adverse effects in numerous studies. The most frequently reported side effects include headaches, dizziness, drowsiness, tremors, migraine, nausea, vomiting, abdominal pain, nightmares, vivid dreams, and irritability. There were even cases of supplement abuse for suicide attempts through melatonin overdose.
The reason for such adverse effects was traced to an incorrect presentation of the amount of melatonin a bottle of supplements truly contains. Investigation shows that melatonin supplement bottles can have 4 times more melatonin than indicated. This can affect ones health significantly, because of the higher the dose, the serious and more frequent side effects.
However, this is not the only reason side effects occur. Sometimes, doctors do NOT prescribe a suitable dosage, or the patients decide to dose themselves as they want. Some people even tend to drink alcohol with melatonin, hoping to emphasize the sedative effects. But, they just cause even more serious side effects.
Are Common Medications Interrupting Your Sleep
The reasons we might experience insomnia or sleep fragmentation are varied.
Emotional stress, pain, sleep disorders, medical conditions, and poor sleep hygiene are the most talked about root causes for sleeplessness.
But what about your prescriptions? Might they be contributing to poor sleep?
Yes. As a matter of fact, there are several common classes of drugs that can cause insomnia. Below, we discuss ten of them.
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Other Possible Melatonin Side Effects
- Melatonin and birth control effects melatonin supplements may not be safe for women trying to get pregnant. It seems that melatonin has similar effects as birth control, making it more difficult for women to reach ovulation and become pregnant. Some evidence shows that lower doses, up to 3mg are safe, but there is not enough research to prove that.
- Melatonin and bleeding disorders it is believed that regular melatonin intake can worsen the symptoms and effects of bleeding disorders. Studies show that melatonin may slow blood clotting or coagulation, which may lead to excessive bleeding and bruising.
- Melatonin and epilepsy studies and current data show that melatonin can trigger or worsen epilepsy and seizure frequency in some people. While some experts argue otherwise, some professionals do not recommend melatonin intake in people who are prone to having epileptic or other types of seizures not even small doses.
- Melatonin and transplant recipients because melatonin can increase the immune function, it might interfere with immunosuppressive therapy used by transplant recipients.
A Fifth Type Of Medication That Affects Brain Function
Opiate pain medications. Unlike the other drugs mentioned above, opiates are not on the Beers list of medications that older adults should avoid. That said, they do seem to dampen thinking abilities a bit, even in long-term users. As far as I know, opiates are not thought to accelerate long-term cognitive decline.
- Commonly prescribed opiates include hydrocodone, oxycodone, morphine, codeine, methadone, hydromorphone, and fentanyl.
- Tramadol is a weaker opiate with weaker prescribing controls.
- Many geriatricians consider it more problematic than the classic Schedule II opiates listed above, as it interacts with a lot of medications and still affects brain function. Its a dirty drug, as one of my friends likes to say.
Frequently Asked Questions About Allegra
Is Allegra-D available by prescription?
While you can get Allegra-D from behind the pharmacy counter in most states, a few states require a prescription. Allegra-D is also considered a controlled substance in states like Oregon.
How long does it take for Allegra-D to work?
This medication starts working within an hour of taking it.
Can I take Allegra-D with juice?
Taking this medication with apple, grapefruit or orange juice can affect the absorption of this medication. It’s recommended to take this medication with only water.
Can pregnant women take Allegra-D ?
Allegra-D should only be used during pregnancy if the benefit justifies the potential risk to the unborn baby. Talk to your provider before starting this medication if you are pregnant.
Can I drink alcohol while using Allegra-D ?
Drinking alcohol while taking Allegra-D can raise your risk of side effects, especially dizziness and drowsiness. It is best to avoid alcohol or limit your intake when taking this medication.
What To Do If You Or Your Relative Is On These Medications
So what should you do if you discover that your older relative or you yourself are taking some of these medications?
If its an over-the-counter anticholinergic, you can just stop it. Allergies can be treated with non-sedating antihistamines like loratadine , or you can ask the doctor about a nasal steroid spray. PM painkillers can be replaced by the non-PM version, and remember that the safest OTC analgesic for older adults is acetaminophen .
If you are taking an over-the-counter sleep aid, it contains a sedating antihistamine and those are strongly anticholinergic. You can just stop an OTC sleep aid, but in the short term, insomnia often gets worse. So youll need to address the insomnia with non-drug techniques.
You should also discuss any insomnia or sleep problems with your doctors its important to rule out pain and serious medical problems as a cause of insomnia but be careful: many of them will prescribe a sleeping pill, because they havent trained in geriatrics and they under-estimate the risks of these drugs.
If one or more of the medications above has been prescribed, dont stop without first consulting with a health professional. Youll want to make an appointment soon, to review the reasons that the medication was prescribed, alternative options for treating the problem, and then work out a plan to reduce or eliminate the drug.
Now go check out those medication bottles, and let me know what you find!
How Long Before Benadryl Makes You Sleepy
Benadryl is quickly absorbed after oral administration and peak effects are reached within one hour. The effects of diphenhydramine last from four to six hours. Benadryl in the injectable form has a rapid onset of action. When used as a night-time sleeping aid, the usual dosage of Benadryl is 50mg at bedtime.
How To Take Melatonin
Use Melatonin exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.
If you choose to use melatonin, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.
Use the lowest dose of melatonin when you first start taking this product.
Take melatonin at bedtime, or when you are getting ready for sleep. If you use this product to treat jet lag, take the melatonin at bedtime on the day you arrive at your destination and keep using this product for 2 to 5 days.
If you take this product to treat other conditions not related to sleep, follow your healthcare provider’s instructions about when and how to take melatonin.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
Do not swallow the orally disintegrating tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device .
Store at room temperature away from moisture and heat.
What The Studies Found
It’s important to note that neither of these studies was a randomized controlled clinical trial, so neither proved that either type of drug causes dementia.
The anticholinergic study. Researchers tracked nearly 3,500 men and women ages 65 or older who took part in Adult Changes in Thought , a long-term study conducted by the University of Washington and Group Health, a Seattle health care system. They used Group Health’s pharmacy records to determine all the drugs, both prescription and over-the-counter, that each participant took in the 10 years before starting the study. Participants’ health was tracked for an average of seven years. During that time, 800 of them developed dementia. When the researchers examined medication use, they found that people who used anticholinergic drugs were more likely to have developed dementia than those who didn’t use them. Moreover, dementia risk increased along with the cumulative dose. Taking an anticholinergic for the equivalent of three years or more was associated with a 54% higher dementia risk than taking the same dose for three months or less.
The University of Washington study is the first to include nonprescription drugs. It is also the first to eliminate the possibility that people were taking the drugs to alleviate early symptoms of undiagnosed dementia. For people who took anticholinergic bladder medications, the increased risk was just as high as for those taking tricyclic antidepressants, which are also anticholinergics.
Who Should Take Sleeping Pills
When a person has insomnia, they may have trouble falling or staying asleep, wake up too early, or not feel refreshed upon waking.
However, many people may not need sleeping pills to treat insomnia. Lifestyle adjustments, such as exercising and avoiding alcohol and nicotine, can often improve a persons sleep cycle and prevent insomnia. Changing the sleep environment, such as replacing an old mattress, might also help.
If making these adjustments does not help treat severe insomnia, a sleeping pill may be a good short-term solution.
There is a range of sleeping pills available to buy, including supplements and other over-the-counter medications. Anyone with ongoing insomnia should consult their doctor about the best approach.
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