Wednesday, October 4, 2023

Does Hyaluronic Acid Increase Estrogen

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Five Common Causes Of Vaginal Dryness:

Estrogen, Skin Aging/Wrinkles & Hyaluronic Acid

1. Estrogen deficiency Low estrogen levels can reduce the natural elasticity and lubrication of the vaginal tissue. The walls of the vagina can become thin and fragile, making them less resistant to injury and trauma. This loss of estrogen is common during peri-menopause, menopause, after childbirth, and during breast feeding. Cancer treatments such as radiation and chemotherapy or surgery that includes removal of the ovaries can lead to an abrupt loss of estrogen. Another common lifestyle cause of vaginal dryness is smoking, which can cause earlier menopause and low estrogen levels.

3. Emotional or Psychological Issues» Lack of arousal, insufficient arousal or sexual problems with a partner can reduce natural lubrication related to a blunted sexual response.» Anxiety and stress can interfere with sexual desire. Addressing underlying tension or worry may be the key to improving dryness symptoms. Men have sex to relax, women need to be relaxed to have sex, says Phil Altman, owner of HealthyChoice Pharmacy, who specializes in compounding bio-identical hormones and non-hormonal vaginal moisturizers.

4. Vaginal Irritants» The vaginal tissues are easily irritated by chemicals and additives in soaps, perfumes, hygiene products, lubricants, laundry detergents and gels. Even dyes on clothing and underwear could result in an allergic reaction.» Beware of reactions to tampons and latex condoms.

What are the symptoms of vaginal dryness?

Hydrating Properties Of Hyaluronic Acid

Hyaluronic Acid is present in our body in a natural way and has an important role in the hydration and elasticity of the tissues, so it is present throughout the body, although in larger quantities in the skin and mucous membranes.

Nearly 50% of the quantities of Hyaluronic Acid are found in our skin, which allows its normal maintenance and moisturizing. As we get older, this amount decreases and our body produces less hyaluronic acid, as well as other key substances for the skin such as collagen. This leads to the skin becoming less elastic, losing moisture and wrinkles may appear.

Effect On Water Content

Healthy skin needs a lot of water. The water content of the skin depends on the evaporation rate through the skin and the hydration of the epidermis . Glycosaminoglycans in the dermis, especially heparan sulfate and versican, are essential for hydration of the skin because they contain large amounts of water. As the amount of glycosaminoglycans decreases with age, the hygroscopicity of the skin also decreases . Hyaluronic acid is abundant in the dermis and is believed to contribute to moisture content, skin atrophy, and the spread of soluble factors and nutrients . In addition, HA can support the proliferative phenotype of fibroblasts and may oppose apoptosis . HA is synthesized at the plasma membrane by hyaluronan synthases . These enzymes extrude HA into the extracellular space after the assembly of uridine diphosphate -glucuronic acid and uridine diphosphate-N-acetyl-d-glucosamine into a growing chain of -linked d-glucuronic acid and N-acetyl-d-glucosamine disaccharides . Repeated disaccharides are linked by hexosamine bonds to form high molecular weight HA that reaches up to 107 Da and 20 μm . HAS is expressed in relatively low copy numbers per cell but can rapidly produce large amounts of HA .

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Whats The Difference Between Vaginal Moisturizersandlubricants

Lets start with the fact that vaginal moisturizers and lubricants are not the same thing. Lubricants do not alter vaginal tissues they just provide a slippery barrier to reduce friction at the time of intercourse. A moisturizer, on the other hand, is intended to change the water content of the cells , resulting in tissues that are more elastic, thicker, and have the enhanced ability to produce fluid. A true long-acting moisturizer is used in anticipation of intercourse, not at the time of intercourse.

Heres where it gets confusing. Just because a product is labeled as a moisturizer, dont assume that it is going to hydrate vaginal tissues. The majority of products that are labeled as personal or feminine moisturizers are not even intended to be put inside the vagina. These products have no long-acting effect on vaginal walls or vaginal lubrication. They are actually intended to lubricate or soften vulvar tissue outside the vagina, but you would never know that from the way the products are labeled.

Just as a face cream can promise to make you look ten years younger with regular use, a feminine moisturizer can claim to make intercourse more comfortable. Unlike with prescription medications, the companies that market these products are under no obligation to the Food and Drug Administration to conduct scientific studies to prove that a product does what it claims to do.

Is Hyaluron A Substance Produced Naturally In The Body

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The gel-like hyaluronic acid has been getting given this appropriate name because it is a transparent substance. Hyaluronic acid is a completely natural component of the skin. As an endogenous substance, hyaluronic acid is getting produced by the connective tissue cells of the subcutis itself.

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  • Amazing Formulas Hyaluronic Acid 100 mg 120 Capsules Support Healthy Connective Tissue and Joints Promote Youthful Healthy Skin
  • NOW Supplements, Hyaluronic Acid, Double Strength 100 mg, with L-Proline, Alpha Lipoic Acid, and Grape Seed Extract, 120 Veg Capsules
  • TruSkin Vitamin C Serum for Face, Topical Facial Serum with Hyaluronic Acid, Vitamin E, 1 fl oz
  • GENIUS Hyaluronic Acid Serum 8OZ, Pure Organic HA, Anti Aging, Anti Wrinkle, The Smart Face Moisturizer for Dry Skin and Fine Lines, Leaves Skin Full and Plump, Pump Bottle by Genius Chemistry
  • Brickell Mens Anti Aging Reviving Day Face Serum for Men, Natural and Organic Serum For Face with Hyaluronic Acid, Protein Peptides to Restore Firmness and Stimulate Collagen, 1 Ounce, Scented

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Does Hyaluronic Acid Affect The Kidneys

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Healthy Foods That Are High In Hyaluronic Acid

Hyaluronic acid is a compound found throughout your body. It plays a key role in many aspects of health, particularly in relation to your skin, eyes, and joints .

For example, studies show that it could reduce the appearance of wrinkles and improve skin hydration, texture, and elasticity (

7 ).

Your body can produce hyaluronic acid, but the compound is also available in oral supplements, injections, and topical products such as serums.

In addition, you can get it from certain foods. Plus, some foods provide nutrients your body uses to boost hyaluronic acid production.

Here are 7 healthy foods that are high in hyaluronic acid or its building blocks.

Bone broth is made by simmering the bones and connective tissue of animals in liquid for 1248 hours.

This results in a flavorful product thats rich in many nutrients, including hyaluronic acid.

Bone broth also contains a good amount of protein, with approximately 10 grams in each 1-cup serving .

Additionally, its a good source of the compounds proline, glutamine, chondroitin, and glucosamine.

Proline and glutamine are two types of amino acids the building blocks of protein. They promote protein production in your body. Chondroitin and glucosamine support joint health .

Plus, its rich in collagen, a type of protein that has been shown to improve skin elasticity and hydration .

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What Is Hormone Replacement Therapy

Hormone Replacement Therapy is a treatment women can receive to relieve the symptoms of menopause. As the name suggests, the HRT treatment replaces hormones that have naturally slowed in their production. HRT can be applied as you approach or during menopause. The prominent advantage of undergoing HRT is the relief of the symptoms common to menopause such as hot flashes, mood swings, night sweats and reduced libido.

So how exactly can HRT change your face? During menopause, the levels of female hormones such as estrogen and progesterone drop. Estrogen and progesterone are the two main sex hormones found in the female body. When you enter menopause, your body will transition from its reproductive stage to the next phase of your life. Becasue of this, your body perceives your sex hormones to be less necessary than they were before, so it reduces their natural production. As mentioned before, estrogen plays an important part in maintaining the health of your skin. This hormone is associated with collagen production, the thickness and hydration of the skin, the healing of wounds, and preservation of the skin barrier.

Can We Eat Hyaluronic Acid


4.3/5Hyaluronic acidHyaluronic acid

Consequently, can hyaluronic acid be taken orally?

There is good reason to believe that orally administered hyaluronic acid is absorbed in the digestive tract and that it does migrate to the relevant connective tissues. There is also evidence that it can have a biological effect without even being absorbed.

One may also ask, is hyaluronic acid bad for your liver? Serum HA increased with severity of liver damage from fatty liver through fatty liver and fibrosis, fatty liver and inflammation, severe fibrosis and inflammation to cirrhosis with the highest of HA levels. Our study showed that hyaluronic acid has the highest diagnostic sensitivity, ACC and NPV in alcoholic cirrhosis.

Additionally, what are the side effects of hyaluronic acid?

Common side effects may include:

  • joint pain, stiffness, or swelling
  • itching, numbness, or tingling
  • swelling, pain, redness, or mild discomfort where the medicine was injected.

When should I take hyaluronic acid?

If you find your skin is really benefiting from the additional hydration, you should apply it once in the morning and once in the evening. The Ordinary Hyaluronic Acid 2% + B5 is water-based so should be applied before heavy oils and creams, all over the face.

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Ha Induces Expression Of Pgrmc1 In Kgn Cells

Because of the correlation of HA with PGRMC1 observed in the patients and the fact that PGRMC1 reportedly plays an important role in the proliferation and function of GCs, we determined whether PGRMC1 was a target gene of HA. We cultured KGN cells in the presence of HA and then quantitatively measured the PGRMC1 mRNA levels by quantitative RT-PCR and the PGRMC1 protein levels by Western blotting. PGRMC1 mRNA levels showed a 1.7-fold increase at 12 h and a 2.0-fold increase at 24 h in the KGN cells in the presence of HA . Dose-response experiments revealed maximal PGRMC1 mRNA induction with 200 g/ml HA after 12 h of treatment in the KGN cells . Furthermore, the PGRMC1 protein level was assessed after treatment with 200 g/ml HA for 24 h and 48 h in the KGN cells. The results showed that PGRMC1 protein levels were also significantly up-regulated in HA-treated cells . Specificity validation analysis revealed that PGRMC1 antibody can detect the 27-kDa form of PGRMC1 in KGN cells .

Culture Of Granulosa Tumor Cells And Rat Primary Granulosa Cells

The KGN cell line , derived from human ovarian granulosa cell tumor that expresses typical GC markers, was cultured in DF-12 medium containing 10% fetal bovine serum and 50 mg/ml penicillin and streptomycin. Rat primary GCs were isolated from female Sprague-Dawley rats as previously described . Briefly, Sprague-Dawley rats were injected subcutaneously with 40 IU of pregnant mare’s serum gonadotropin at 28 days of age to stimulate the development of preantral follicles. After 48 h, GCs were released by puncturing follicles. Cells were pelleted at 100 × g for 15 min, counted using trypan blue, and plated at a density of approximately 1 × l06 cells/ml on plastic dishes coated with 0.5 mg/ml human plasma fibronectin in Dulbecco modified Eagle medium/Ham F-12 medium with 15 mM HEPES, 3.15 g/L glucose containing 10% FBS, and 50 mg/ml penicillin and streptomycin. All animal experiments were performed according to the guidelines of the Experimental Animals Management Committee .

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Who Experiences Vaginal Dryness

Dryness can occur in adult women of any age, due to a wide range of causes. Roughly 20% of women under the age of 60, and two-thirds of women over the age of 60 say that vaginal dryness is one of their top sexual health problems. The culprit is typically linked to changes or fluctuations in hormone levels but, not always. We also know that this dryness can cause pain, discomfort, itching, and is likely to have an impact on intimacy.

Here are the most common reasons for vaginal dryness:

If these symptoms sound familiar, you arent alone. The first step you should take when experiencing vaginal dryness is to consult your doctor. Your physician or healthcare provider can help understand the cause and recommended treatments.

Improper Uses Of Hyaluronic Acid

What You Dont Know About Hyaluronic Acid (But Should ...

Applying hyaluronic acid to dry instead of damp skin, can have a dehydrating effect. Since it moisturizes by attracting water, in a dry environment it will pull moisture from the deeper layers of the skin. This can result in skin feeling dry, tight and uncomfortable.

Additionally, getting too many injections in the same arearegardless of ingredientincreases the risk of developing an infection at the injection site.

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Does It Come In Supplement Form

Essentially, hyaluronic acid is a dietary supplement said to reduce the accumulation of fluid and decrease inflammation in the joints and connective tissues of the body. Typically, it is found in tablet form and taken in a 40 or 50 milligram dosage twice a day, but can be given hypodermically to the affect area. The tablets are not a prescription medication, so bottles of hyaluronic acid can pretty much be found anywhere that sells vitamins and supplements, this would include pharmacies, big box stores and supplement dealers like GNC and Vitamin World.

Vaginal And Vulvar Moisturizers

Vaginal and vulvar moisturizers help to increase moisture in your vagina and vulva and improve tissue quality. These products are different from lubricants, which are used during sexual activity. Vaginal and vulvar moisturizers can be used at any time, not just before or during sexual activity. You should use vaginal and vulvar moisturizers several times a week for overall vaginal health and comfort.

Over-the-counter vaginal and vulvar moisturizers are non-hormonal. You can buy them online or at your local pharmacy without a prescription.

The following are examples of vaginal and vulvar moisturizers:

Hydrating types

  • Hyaluronic Acid Products
  • This moisturizer can be inserted into your vagina with a disposable applicator , put on your vulva, or both.
  • You can buy HYALO GYN online at
  • Revaree®
  • This moisturizer is a suppository . You apply it to the inside of your vagina.
  • You can buy Revaree online at Use code MSKREV25 at checkout to get 25% off your first month when you order a monthly subscription of Revaree. This is offer is only for subscriptions.
  • Replens Long-Lasting Vaginal Moisturizer
  • This vaginal moisturizer can be inserted into your vagina with a disposable applicator, put on your vulva, or both.
  • You can buy Replens Long-Lasting Vaginal Moisturizer at your pharmacy.
  • Soothing types

  • Natural oils, such as vitamin E or coconut oil
  • These can be used inside or outside of your vagina.
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    Soya Are Foods Rich In Hyaluronic Acid

    Researchers believe that estrogen in the body is beneficial for hyaluronic acid production. Soy products like tofu, tempeh, or edamame all products made from soybeans all contain estrogen. Soy is one of the best sources of protein. Even as a convinced meat lover, you should include tofu in your diet from time to time. If you dont like tofu, you can use soy milk instead. The vegetable milk has a nutty taste that goes well with any muesli.

    Vaginal Dryness The Non

    What Is Hyaluronic Acid and How Does It Help Your Skin?

    Vaginal dryness is perhaps the most distressing and least talked about symptom of menopause and post menopause. This silent epidemic that affects about 20 percent of women in those groups, sometimes transiently and other times permanently, can result from the changes that occur when estrogen levels decline causing the vagina and surrounding connective tissue to lose elasticity, and the tissue that lines the vagina becomes thinner and more fragile. It can not only affect quality of life and make sex uncomfortable but can also cause vaginal irritation, soreness, and itching.

    Although there are hormone based creams containing estrogen available, many women choose not to use this option because of the fear of estrogen being absorbed and potentially increasing their breast cancer risk. For women who have had breast cancer, the use of aromatase inhibitors is associated with a significantly greater incidence of vaginal dryness compared with tamoxifen. Increasing use of AIs means that the number of women complaining of vaginal dryness following breast cancer treatment is on the rise.

    So what should you do if youre experiencing vaginal dryness and irritation, but dont want the risks of systemic estrogen exposure?

    A cream containing Hyaluronic Acid, Vitamin E, Vitamin A and Aloe is just the answer many women are seeking.

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    Benefits Of Hyaluronic Acid For The Face And Body

    Hyaluronic acid is a sugar that occurs naturally in the body, including the skin, eyes, and joints. The primary function of hyaluronic acid is to provide moisture to these areas of the body.

    Hyaluronic acid plays a crucial role in skin moisture. As people age, the moisture in their skin , so some people choose to take supplemental hyaluronic acid.

    This could be in the form of oral supplements, topical creams, serums, or even injections.

    This article provides 11 evidence-backed benefits of using hyaluronic acid for the face and body. It explains how often a person can use hyaluronic acid and discusses types and side effects.

    Many people use hyaluronic acid to hydrate their skin. People can take hyaluronic acid as a supplement, or they can apply it topically as a cream.

    Hyaluronic acid can skin moisture and improve the quality of life for those with dry skin.

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