New Drug Could Treat Low Testosterone With Fewer Side Effects
30 July 2014
In fertility treatment, what’s good for the goose apparently is good for the gander. A new study shows that a drug similar to one used to help women ovulate can raise testosterone levels and sperm counts in men.
The drug, called enclomiphene citrate, may prove to be more effective in treating men with low testosterone than the testosterone gels and injections currently prescribed. That’s because the medicine helps the body produce its own testosterone and may be cheaper and more convenient to use.
The new study, a phase II clinical trial, will appear in an upcoming issue of the journal Fertility and Sterility. A phase II clinical trial is the second of four phases used to test a drug for safety and effectiveness before it is submitted to the Food and Drug Administration for approval.
Low testosterone, or hypogonadism, affects millions of U.S. men, according to the Centers for Disease Control and Prevention. Symptoms of the condition include fatigue, loss of muscle mass, an increase in body fat, depression, erectile dysfunction and low libido. Testosterone levels in men drop naturally after about age 30, but lower-than-normal levels are also associated with obesity, diabetes and circulatory disease.
“This is a complicated problem that requires expert consultation before embarking on treatment,” said Dr. Lawrence Ross, a urologist and professor emeritus at the University of Illinois at Chicago, who did not work on the new study.
Testosterone up, but sperm down
The Use Of Clomiphene Citrate In Young Adults With Low Testosterone And Symptoms Of Hypogonadism
Leonardo de Souza Alves1*, Mikhail Ruzaev2, Mirab Guseynov3
1) MD, Instituto de Urologia e Andrologia. Sociedade Brasileira de Urologia. American Urologic Association. European Urologic Association. Fellow in Andrology Memorial. Sloan Kettering Cancer Center NY/USA 2) MD, Phd European Urologic Association Nucleomed Clinic, Moscow 3) MD European Urologic Association Institute of Post-Graduate Education of Andrology of Russia
Abstract
Background: Clomiphene Citrate is a selective estrogen receptor modulator that has been used in women to induce ovulation for years. Recently Clomiphene Citrate has bee used as an off label treatment in men with hipogonadism. CC acts centrally inducing production of Testosterone and improving spermatogenesis.
Methods: From March 2016 to January 2019, 46 patients were observed. They received a prescri ption of CC, 50 mg/daily, during 6 months. All patients had Total Testosterone levels less than 300 mg/dl, associated to sign and symptons of Hipogonadism .
Results: After 180 days of CC prescription, 34 patients from 46, had raised levels of Total Testosterone.
INTRODUCTION
Clomiphene citrate is drug used frequently in ovarian stimulation procedure. However, it has been used as off label therapy in men, to achieve testicular stimulation to increase testosterone levels, as an alternative way, from use of testosterone replacement therapy .
OBJECTIVE
MATERIAL
RESULTS
DISCUSSION
REFERENCES
Expectations And Results From Clomid Dosages
Clomid generally serves as an effective endogenous Testosterone production stimulating compound, ideal for proper hormonal recovery following the end of an anabolic steroid cycle. Although it can be used for the treatment or reversal of early development gynecomastia, it is not recommended due to its poor ability at achieving such an effect, where Nolvadex is the preferred agent of the two.
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Proper Administration And Timing Of Clomid Dosages
There are no special considerations in regards to the administration of Clomid. It can be taken before, during, or after meals. It can also be consumed in the morning or at night time. It is recommended to ingest the full dose all at once as opposed to splitting the Clomid doses up throughout the day, which is largely unnecessary due to its long half-life of 5 7 days.
If You Want To Boost Testosterone Levels But Do Not Want To Compromise Fertility What Can You Do
Clomid uses a different approach to increase testosterone and spermatogenesis. It was originally developed and tested to increase ovulation and, thereby, improve fertility in women. The result in men is a modest improvement in testosterone levels while preserving sperm production. We can usually achieve a 100% increase in T levels with Clomid. In some cases, one may see up to a 200% increase. This increase is not as high as pellets or injections but it can make a big difference depending on how low you are. So if you had an initial level of 300, we would hope to see an increase to 600, +/-. Some clients may even see a larger increase.
DIAGNOSIS & TREATMENT OF LOW T
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Clomiphene For Testosterone Optimization
The use of the medication Clomiphene or Clomid as it is more widely known, is not yet a well-known treatment for testosterone optimization. However, Clomid does have a number of advantages over testosterone that should be discussed with your doctor. This blog explores Clomid for testosterone optimization; including what it is, how it works, side effects, advantages over testosterone and who this medication is and isnt for.;
1. What is clomiphene?
Clomiphene, more commonly referred to by its brand name Clomid, is a medication that was approved by the FDA following successful clinical trials in 1967. It has been used for a long time to treat infertility in women. More recently, it has come into use to treat infertility as well as to increase testosterone levels in men.
2. How does Clomid work?
Clomid is taken as a pill. In both women and men, it works at the level of the pituitary gland which is a primary controller of hormone production in the body. In men, Clomid causes the pituitary gland to increase the hormonal signals to the testicles to increase testosterone and sperm production.
3. What are the risks of using Clomid?
4. What is the advantage of using Clomid over testosterone?
5. Who is Clomid for/not for?
6. Is Clomid covered by health insurance?
7. How can I use Clomid?
What Are The Benefits Of Clomid Over Traditional Testosterone Injections Or Pellet Trt
Clomid for men stimulates the bodys own production of testosterone. Clomid is a pill taken daily. It is generic and cheap. No shots. It does not interfere with the bodys checks and balances of testosterone. Fertility is preserved. No testicular shrinkage. It has few, if any, side effects and this is usually dose-related. Clomid, by increasing T levels, can produce the same/similar effects as traditional TRT. Each patient is different and the response will vary depending on current testosterone level. It is inexpensive and usually covered by health insurance.
Clomid, by increasing T levels, can produce the same/similar effects as traditional TRT. Each patient is different and the response will vary depending on current testosterone level
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Clomid For Men Is Used When A Low Sperm Count Is Caused By Low Testosterone Levels
In some men, a low sperm count is caused by a low testosterone level. It might seem logical to give more testosterone to a man with a low testosterone level; however, doing so can actually decrease his sperm count. A similar situation exists in women, as birth control pills with estrogen prevent egg development and ovulation.
- In women, FSH and LH induce egg development and ovulation.
- In men, FSH leads to an increase in sperm production and LH leads to an increase in testosterone production.
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Other Male Fertility Pills And Medications
Alternative oral medications that are used to treat male fertility include:
- Letrozole or Femara: Letrozole is an aromatase inhibitor .; It is an exciting new male fertility treatment that has been shown to improve sperm concentration and the testosterone to estradiol ratio for men with oligozoospermia.
- Anastrazole or Arimidex: Anastrazole is another aromatase inhibitor that works to decrease the production of estrogen and increase testosterone in the body.; Research shows that Anastrazole can help to reduce testosterone levels, improve the ratio of testosterone to estradiol, and significantly improve sperm parameters.;
In addition to oral medications, male infertility can also be treated via injectable medications like human chorionic gonadotropin or human menopausal gonadotropin .;;
Human Chorionic Gonadotropin : hCG has been shown to help induce testis growth, improve spermatogenesis and increase fertility in gonadotrophin-deficient men .;;
Human Menopausal Gonadotropin: If men dont see results after an extended period of time with hCG treatment, hMG injections may be added to their treatment protocol.; In combination, hCG and hMG have been shown to increase sperm count and motility.
This Inexpensive Drug Dramatically Increases Testosterone And Improves The Testosterone/estrogen Ratio With No Side Effects
Several years ago a friend of mine, an internist, told me what he was doing for some of his patients who were in need of testosterone replacement therapy . He didnt give them testosterone gels, creams, or even shots.
Instead, he wrote them prescriptions for clomiphene citrate, aka Clomid, a female fertility drug thats also used to stop the growth of estrogen-dependent breast cancer.
Granted, Clomid has a long history in competitive bodybuilding as an anti-estrogen and something that could help restore testicular function while coming off a steroid cycle. Still, its never been routinely used as an alternative to TRT, so when my friend told me about what he was doing with it, I chalked up his concept as too iffy, too underpowered, and maybe a little too whacky to be taken seriously. Just Joel being Joel.
Recently, though, while researching another topic, my Googling took a right turn instead of a left and I ended up finding some studies that backed up what Joel was doing. It seems Clomid may turn out to be cheaper than TRT, possibly equally effective, and with fewer side effects.
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Symptoms Of Declined Testosterone Levels
The treatment method of testosterone replacement isnt alarming as testosterone greatly enhances the quality of life for a male. Not only does it improve muscle mass, but it also supports a vibrant sexual experience. In short, replacing a hormone that allows them to feel and perform better is perfectly normal.When testosterone levels drop, a young male might experience low libido, erectile dysfunction, weight gain, poor concentration, depression, etc. Like mentioned before, many of these symptoms mirror that of an aging man.
Fatigue that cant be cured with sleep is one of the biggest indicators of low testosterone. Typically that type of fatigue coupled with low libido brings a young man into the doctors office for a check-up.
Clomid For Men Can Increase Sperm Count And Increase Testosterone Levels
Some men with abnormal semen parameters also have low testosterone production. In many of these cases, medical treatment will successfully increase both sperm count as well as testosterone production. A man should NOT start taking testosterone if pregnancy is the goal, as testosterone supplementation will lead to a significant reduction in sperm count, possibly even to undetectable levels.
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Why Clomid Might Be A Viable Treatment
Traditional testosterone replacement therapy can be somewhat questionable for younger men because it can interfere with fertility. For instance, it often negatively impact sperm production in the testes and possibly even lessens the likelihood of conceiving a child in the future.
But Clomid doesnt carry the same risk as other traditional testosterone replacement therapy. Since it supports sperm maturation and stimulates testosterone production by releasing LH and FSH, it acts as a sort of two-for-one. It increases testosterone levels and virility at the same time.
Granted, too much of anything is unhealthy, including testosterone. Should you choose to take Clomid, your doctor will test your testosterone level a few weeks after initially starting the drug to make sure its at a healthy level.If youre ready to begin your journey with testosterone replacement therapy, please contact me. I can help you navigate through all the complexities of hormone replacement and would be happy to answer any questions you might have.
Who Is Clomid Recommended For
Clomid is usually recommended for men who have infertility, who also have low testosterone.;
One of the easiest ways to test a mans fertility is through a semen analysis test.; A semen analysis checks the count, shape, ability to move, and overall health and viability of a mans sperm.;
All it takes to check your testosterone levels is a simple blood test.; Testosterone blood tests are usually completed in the morning as that is when testosterone levels are the highest.;;
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Is There Any Downside To Clomid Therapy
In lower levels of testosterone, it takes longer to see the benefits of Clomid than with injection therapy. It may also not work, especially in patients over 60 and those with compound medical issues. Some patients may not see an increase in libido as Clomid does have some mild estrogenic properties. Of course, we follow the labs, just like in TRT, and would correct for an elevated estradiol level if needed . There have been rare reports of vision changes. If this happens, the patient should note very specifically what occurred, how long it lasted, etc. and then stop the Clomid until you speak with your doctor.
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Clomiphene May Offer Alternative For Treating Low Testosterone
Evidence continues to accumulate that clomiphene citrate , approved in the U.S. for the treatment of ovulatory dysfunction in women, may be an effective therapeutic option for men with hypogonadism.
New York-Evidence continues to accumulate that clomiphene citrate , approved in the U.S. for the treatment of ovulatory dysfunction in women, may be an effective therapeutic option for men with hypogonadism.
The most recent studies of the effects of the agent in older men were presented at the 2010 AUA annual meeting in San Francisco by Darren Katz, MD, a former urology research fellow at Memorial Sloan-Kettering Cancer Center in New York who is now the urology registrar at the Monash Medical Center, Melbourne, Australia.
“The take-home is that clomiphene citrate may provide an efficacious alternative to testosterone,” Dr. Katz told Urology Times. “It can be used in older men and it can be used long term. It is a well-tolerated drug.”
Clomiphene is finding increased use as a therapy for younger men due to the absence of concerns about testicular atrophy, said Dr. Katz, who worked on the study with John P. Mulhall, MD, and colleagues.
The Sloan-Kettering team decided to look at the effects of the drug in an older cohort of 96 men aged 50 to 70 years with documented hypogonadism. Significant percentages of the cohort presented with co-morbidities. More than one-third had hypertension, 14% had diabetes, and 39% had dyslipidemia. At baseline, 74 of the men had abnormal bone density.
When Testosterone Therapy Might Help
Men who are no longer interested in conceiving may benefit from safe, monitored testosterone replacement therapy. Some patients with genetic issues that cause subfertility, such as Klinefelter’s syndrome, may also benefit.
Natural options
- Lose a few pounds: Approximately 30% of obese men have low-T. Since muscle burns more calories than fat, the more muscle you have, the less likely your body is to store excess calories as fat. However, some research suggests that low-T contributes to weight gain it’s a vicious cycle. Start by cutting belly fat, which is good for your heart health and general wellness.
- Eat a healthy diet: For full-body health and hormone balance, consider the Mediterranean diet, which focuses on lean proteins, healthy fats, and plant-based foods. Also enjoy foods that are high in vitamin D, which supports testosterone production, strong bones, and mood. Some of these include eggs, salmon, and mushrooms.
- Rethink online viewing habits: Pornography is readily available online and it can perpetuate skewed expectations for what masculinity and sexual virility should feel like. Your body was not designed to perform sexually for hours on end what you’re seeing on the screen is cinematography, not reality.
Medication options
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Clomid Dosage During Anabolic Steroid Use
Although Nolvadex is the more potent, better suited, and stronger choice over Clomid for the mitigation of gynecomastia during cycles, Clomid;can indeed be utilized for this purpose. Nolvadex, however, should be the first and foremost choice among anabolic steroid users for this purpose, and is normally the only choice among experienced anabolic steroid users.
For the purpose of gynecomastia prevention/reduction during a cycle: Although Clomiddoses are not normally utilized for either the prevention of the development of gynecomastia during an anabolic steroid cycle, the Clomid doses are approximately 50 100mg daily during an anabolic steroid cycle. Some individuals have found that Clomids effectiveness as an Estrogen antagonist in breast tissue is in fact so weak compared to Nolvadex that Clomid doses might require even higher administrations above 100mg daily.