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Liletta Iud Hormonal Side Effects

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Similarities In All Iuds

Physician Assistant explains the Liletta IUD

An IUD is a convenient method of birth control. There is no intake of pills required, which might be problematic if you forget to take them or are on antibiotics. There is also no need for a condom every time you want to get intimate with a partner.

As mentioned above, there are two types of IUDs. Hormonal and Non-Hormonal. They function differently, but there are quite a few similarities between all of them. Both IUD types are similar in shape. They are T-shaped devices that are inserted into the uterus through the cervix. The procedure to insert the device is also the same.

One appointment with the doctor and the device can be added. Sometimes a woman might need a dilator, but that applies to any type of IUD.

Both IUD types stop sperm movement and prevent pregnancies. The sperm is stopped from meeting the egg, which can then become an embryo. All of them are highly effective birth control methods on their own.

If you remove the IUD, then your fertility can be back to normal, and women can get pregnant. Most can be used and kept in the uterus for a good number of years. There are a few brands that have a life of three years, but most have it from 5-10 years.

For those years, the users can be free from the stress of an unwanted pregnancy. One can remove IUD anytime. Women who are not satisfied with the side effects or may want to have children again can go to the doctor for the removal, even before the expiry date.

Access Ius: A Comprehensive Contraceptive Efficacy And Safety Study Of An Ius

ACCESS IUS was designed to assess the efficacy and safety of Liletta among a diverse population of women in the United States. It is a multicenter, phase 3, open-label clinical trial conducted at 29 sites in the United States including public, private, and university institutions. Of 1751 women, 1600 participants were aged 16 to 35 years and included in efficacy assessments and 151 participants aged 36 to 45 years were included for overall safety evaluation. The primary outcome was on-treatment pregnancy, defined as any pregnancy with a date of conception beginning with the day of Liletta placement and through 7 days after IUS discontinuation.14,15,17-22

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Other Side Effects Of Liletta

Some side effects of levonorgestrel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Hormonal Iud Side Effects

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There are four brands of hormonal IUDs Mirena, Skyla, Kyleena, and Liletta. All use a hormone called progestin, which prevents fertilization by thickening the cervical mucus, thinning the uterine walls, and possibly stopping ovulation. These IUDs last different lengths of time, between three to seven years.

There are specific side effects to keep in mind when considering the hormonal IUD:

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What Are Common Side Effects Of Mirena

The most common side effects of Mirena® happen during or shortly after IUD placement. These effects tend to go away on their own. In the week after IUD placement, some women experience:

Getting pregnant with an IUD is uncommon but possible. You should seek medical care if you have any reason to believe you may be pregnant when you have an IUD.

What Is The Most Important Information I Should Know About Liletta

An IUD can increase your risk of developing a serious pelvic infection, which may threaten your life or your future ability to have children. Ask your doctor about this risk.

Do not use during pregnancy. If left in place during pregnancy, this IUD could cause severe infection, miscarriage, premature birth, or death of the mother. The hormone in the IUD may also cause unwanted effects in a female newborn.

Tell your doctor right away if you become pregnant. If you continue the pregnancy, watch for signs such as fever, chills, cramps, vaginal bleeding or discharge.

You should not use this device if you are allergic to levonorgestrel, silicone, silica, silver, barium, iron oxide, or polyethylene, or if you have:

  • abnormal vaginal bleeding that has not been checked by a doctor
  • an untreated or uncontrolled pelvic infection
  • endometriosis or a serious pelvic infection following a pregnancy or abortion in the past 3 months
  • pelvic inflammatory disease , unless you had a normal pregnancy after the infection was treated and cleared
  • uterine fibroid tumors or conditions that affect the shape of the uterus
  • past or present cancer of the breast, cervix, or uterus
  • liver disease or liver tumor
  • a condition that weakens your immune system, such as AIDS, leukemia, or IV drug abuse
  • if you have another intrauterine device in place
  • if you had an abortion or miscarriage in the past 6 weeks or
  • if you gave birth to a baby in the past 6 weeks.

Tell your doctor if you have ever had:

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When Should You Get Liletta

You should have your Liletta IUD inserted sometime during the first seven days of your menstrual cycle or immediately after a first-trimester abortion or miscarriage. If you have Liletta inserted during this time, it is immediately effective, so you do not need backup birth control.

If you have your Liletta IUD inserted at any other time during your monthly cycle, you will need to use another birth control method during the first week after having Liletta inserted. Your pregnancy protection will begin after seven days.

You should wait at least six weeks to have Liletta inserted after giving birth or undergoing a second-trimester abortion or miscarriage. This time frame will give your uterus time to fully heal before having your Liletta IUD inserted.

How Does The Mirena Work

Will I Gain Weight With an IUD? (IUD FAST FACT #16, @dr_dervaitis)

The Mirena IUD, like all hormonal IUDs, contains a synthetic hormone called Levonorgestrel, a progestin, that it slowly releases in your body over time. While progestin sounds like progesterone, it is not, nor does it behave like progesterone in your body.

Instead, the progestin released thins the lining of your uterus, the endometrium, so a fertilized egg would be unable to implant. This is one way in which women have lighter or absent periods while using a hormonal IUD.

It is also designed to stop ovulation by suppressing the production of two brain hormonesFollicle Stimulating Hormone and Luteinizing Hormone . FSH and LH work together to mature an egg and trigger ovulation. They are also responsible for signaling the rise and fall of your hormones. It also thickens cervical secretions, making it difficult for sperm to make it to the egg in the event ovulation does occur.

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What Is An Iud

IUDs are small, usually T-shaped devices made of flexible plastic or copper. In a short, simple medical procedure, a doctor or healthcare provider places the device inside the uterus. After placement, an IUD provides continuous pregnancy protection for several years.

There are two main types of IUDs:

  • Hormonal IUD: This type of IUD works by releasing a small amount of the hormone progestin. Four brands of hormonal IUDs are available today in the U.S.: Mirena®, Liletta, Kyleena®, and Skyla®.
  • Copper IUD: ParaGard® is a hormone-free IUD wrapped in a small piece of copper. The copper causes sperm to avoid the area around the IUD. Because the copper helps stop sperm from reaching an egg, the IUD prevents pregnancy.

Contraceptive Efficacy Through 6 Years

Of the 1751 women enrolled, successful placement among women who had attempted IUS placement was 98.7%.17 Reasons for unsuccessful placement included inability to sound the uterus and uterine measurement by sounding less than 5.5 cm . There were two pregnancies in the first year one intrauterine pregnancy after Liletta IUS expulsion and one ectopic pregnancy associated with a uterine perforation. The Pearl Index is 0.15 through year 1.14 By the end of the fifth year, there were nine total pregnancies in over 1500 women, representing over 6300 28-day cycles.18

Of the nine pregnancies, six were ectopic, resulting in an ectopic pregnancy rate through 5 years of 0.13 per 100 woman-years.18 There were no pregnancies reported year 6.17 Pregnancy rates are presented in Table 1.17 Based on these data, the FDA approved Liletta to be utilized for pregnancy prevention for 6 years in October 2019, and the study is ongoing through 10 years of IUS use.17

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What Are The Different Types Of Iuds

An IUD is a small T-shaped device thats placed inside the uterus by a physician. There are two kinds of IUDs: hormonal and non-hormonal/copper.

  • Hormonal IUDs release a daily amount of progestin into your uterus. The probability of getting pregnant using this method ranges between 0.1 and 0.2 percent.
  • A non-hormonal/copper IUD prevents pregnancy by creating an inflammatory response in the uterus making it impossible for sperm or ova to survive. The probability of pregnancy using this method ranges between 0.5 and 0.8 percent.

What Patients Should Know About The Liletta Iud

Hormonal IUD

Posted on by Capital Women’s Carein Gynecology

Intrauterine devices, abbreviated as IUDs, have been growing more and more popular among American women over the last few years. Liletta is both highly effective and lasts for 3-5 years, making it an excellent option for those considering a long-lasting form of birth control!

Of course, before you run in to your OBGYNs office to get this IUD, there are a few other key points that you should know about Liletta.

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Bleeding And Amenorrhea Rates Using Liletta

In addition to its high efficacy in pregnancy prevention, Liletta has also been extensively studied to evaluate its bleeding profile during use. Amenorrhea secondary to hormonal contraception is often a

desirable characteristic, as evidenced in the ACCESS IUS trial in which only one participant discontinued Liletta due to amenorrhea.18 Mirena is reported to have a 20% amenorrhea rate in the first year of use 3 but generalizability is limited due to the skewed population of normal-weight, multiparous, white women who had used an intrauterine method previously.21 So, investigators used the ACCESS IUS data to evaluate amenorrhea and bleeding patterns in detail over the first year of use.21

In the first year, 28 women discontinued levonorgestrel IUS use for bleeding complaints. Among women who had not previously used a levonorgestrel IUS, amenorrhea rates were 17%, which was the same rate at 9 and 12 months.21 Among women using a levonorgestrel IUS prior to enrollment, the amenorrhea rates are 35% at 9 and 12 months.21 Amenorrhea rates in levonorgestrel 52-mg IUS users continue to rise over 6 years. At the end of 2 and 3 years, 27% and 36% of users reported amenorrhea the previous 90 days of years 2 and 3, respectively.22 The rate remains about 40% in years 4, 5, and 6.17,18

Liletta Ius: Not Just For Long

Suji Uhm, MD, MPHContemporary OB/GYN Journal

Liletta is under study in a prospective phase 3 clinical trial aimed at extending the approved duration of this levonorgestrel 52-mg IUS.

Introduction

Of women using reversible contraception in the United States, 16% use an intrauterine device equaling 4.4 million women in 2014.1,2 Today, five IUDs are available: Paragard®, a non-hormonal copper IUD, and four hormonal intrauterine system products containing levonorgestrel Liletta®, Mirena®, Kyleena® and Skyla®. These systems are categorized by the amount of levonorgestrel that they contain -52, 19.5 or 13.5 mg. The amount of hormone drives the efficacy, bleeding profile, and recommendations for length of use.

The 52-mg IUS has gained popularity as a highly effective, reversible contraceptive because of several advantages, including the ability to significantly decrease menstrual blood loss and improve dysmenorrhea. The US Food and Drug Administrations first approval of a 52-mg IUS was for Mirena for a 5-year duration. In 2009, an indication for treatment of heavy menstrual bleeding was added.3 The second levonorgestrel 52-mg IUS, Liletta, was initially approved for 3 years for contraceptive use in 2015 and, as of October 2019, is approved for up to 6 years.4

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How Effective Is The Mirena Iud

Mirena® is more than 99% effective. Out of 10,000 women who use Mirena® for birth control, approximately six may get pregnant unintentionally. Outside of abstinence , IUDs are significantly more effective than most common forms of birth control options:

  • Shot : 94% effective .
  • Pill, patch, and vaginal ring: 91% .

What Are The Risks Of Using An Iud

What is an IUD? Learn About IUD Effectiveness | Planned Parenthood Video

Although IUDs are safer than ever before, its still too soon to tell if some listed long-term risks are truly likely.

For example, the package inserts for Mirena, Liletta, Skyla, and Kyleena all advise against use if youve ever had breast cancer. But there hasnt been any conclusive evidence about an increased risk of cancer.

Some and possibly even cervical cancer.

Other risks are established, but still quite rare. These include pelvic inflammatory disease and perforation.

If youre concerned about your potential risk, talk with a clinician. Be prepared to discuss your genetic or family medical history. This can help inform the decision you and your clinician make about birth control.

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How Do Iuds Work

An IUD is a tiny, T-shaped piece of flexible plastic that is inserted into your uterus by a medical provider. We mentioned earlier that the hormonal IUDsMirena, Skyla, Kyleena, and Lilettaall work by releasing the hormone levonorgestrel, a form of progestin. Levonorgestrel works by thickening the cervical mucus, which blocks the sperm from meeting up with an egg.1 If a highly motivated sperm does make it through, progestin also thins the lining of the uterus making implantation unlikely to occur.

Paragard, the only non-hormonal IUD, has copper wire coiled around it. That copper produces an inflammatory response in the uterus thats toxic to sperm and it interferes with its movement, making it nearly impossible to have a meet-and-greet with an egg, according to the American College of Obstetricians and Gynecologists .

How Is Liletta Used

You may feel pain or dizziness during insertion of the IUD, and you may have minor vaginal bleeding. Tell your doctor if these symptoms last longer than 30 minutes.

The IUD should not interfere with sexual intercourse, wearing a tampon or menstrual cup, or using other vaginal medications.

Your doctor should check the IUD after a few weeks to make sure it is still in place. You will also need annual pelvic exams and Pap smears.

You may have irregular periods for 3 to 6 months. Your flow may be lighter or heavier, and your periods may stop after several months. Tell your doctor if you do not have a period for 6 weeks or if you think you might be pregnant.

The IUD may come out by itself. After each menstrual period, make sure you can still feel the removal strings at the opening of your cervix.

If you need to have an MRI , tell your caregivers ahead of time that you have an IUD in place.

Your IUD may be removed at any time you decide to stop using birth control. Mirena or Liletta must be removed at the end of the 6-year wearing time. Kyleena must be removed after 5 years, and Skyla must be removed after 3 years. Your doctor can insert a new device if you wish to continue using this form of birth control. Only your doctor should remove the IUD. Do not attempt to remove the device yourself.

If you decide to use a different method of birth control, you may need to start using it a week before your IUD is removed.

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Liletta Pros And Cons

When opting for a birth control option, its important to consider all of the facts before making a decision. Heres a breakdown of the Liletta pros and cons to help you determine if this IUD is right for you.

Pros of the Liletta IUD

  • Long-term, reversible birth control option
  • Helpful for family planning
  • Safe for mothers who are breastfeeding
  • Over 99% effective at preventing pregnancy
  • Unlike the pill, it doesnt need to be taken daily

Cons of the Liletta IUD

  • Can experience mild to severe side effects
  • Can be costly if uninsured and ineligible for savings programs
  • Unsafe for women who have or have had breast cancer
  • Cannot be used as emergency contraception
  • Unsafe for women who can get infections easily

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