References Related To Testosterone Estrogen And Pellet Implant Therapy
Summary And Quick Facts For Female Hormone Restoration
- Life Extension has long recognized the value of bioidentical hormone replacement therapy, which uses hormones that are identical to those naturally produced in the body. The appeal of bioidentical hormone therapy has not been lost on the public or the medical community: nearly one-third of women who now use hormone therapy do so with bioidentical hormones.
- In this protocol, you will learn how to approach bioidentical HRT judiciously. You will also learn how using readily available blood tests may help guide your therapy in partnership with a qualified healthcare provider.
- In addition to estrogens, a comprehensive hormone restoration program may include progesterone, DHEA, pregnenolone and possibly testosterone. Dietary and supplemental phytoestrogens present a way for women to obtain limited hormonal support without the use of hormone therapy.
Warnings Of Estriol And Estradiol
Using estrogen can increase the risk of endometrial cancer, especially when its not taken with a progestin. Estriol and estradiol also have an increased risk of heart attack , stroke, pulmonary embolism , and deep vein thrombosis in postmenopausal women aged 50 to 79 years old. In the same population of women, estrogen use can also lead to an increased breast cancer risk, according to the Womens Health Initiative. Estrogen may also increase the risk of dementia in some postmenopausal women over 65 years of age.
Consult a doctor if you have risk factors including a medical history of:
- Heart attack
- Endometriosis
- Hypocalcemia
Women who smoke tobacco may be at an increased risk of blood clots. Estrogen-containing products should not be used in these women.
Estriol, estradiol, and other estrogen-related drugs can harm an unborn baby. They should not be used during pregnancy or breastfeeding.
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When Is The Right Time For Hormone Replacement Therapy
When one becomes deficient in any hormone, it is optimal to replace it. Generally women will become deficient in progesterone and/or testosterone in their late 30s to early 40s. A lack of estrogen usually doesnt occur until shortly before or at the menopause . Replacing all three hormones after the menopause is usually necessary for optimal hormone balance.
Estrogen Treatment: Topical Creams Gels And Sprays
- What are they? Estrogen gels , creams , and sprays offer another way of getting estrogen into your system. As with patches, this type of estrogen treatment is absorbed through the skin directly into the bloodstream. The specifics on how to apply these creams vary, although theyre usually used once a day. Estrogel is applied on one arm, from the wrist to the shoulder. Estrasorb is applied to the legs. Evamist is applied to the arm.
- Pros. Because estrogen creams are absorbed through the skin and go directly into the bloodstream, theyre safer than oral estrogen for people who have liver and cholesterol problems.
- Cons. Estrogen gels, creams, and sprays have not been well-studied. While they could be safer than oral estrogen, experts arent sure. So assume that they pose the same slight risk of serious conditions, like cancer and stroke.One potential problem with using this type of estrogen treatment is that the gel, cream or spray can rub or wash off before its been fully absorbed. Make sure you let the topical dry before you put on clothes. Always apply it after you bathe or shower.
Because the estrogen is absorbed right through the skin, dont let other people in your family touch these creams or gels. If they do, they could get dosed with estrogen themselves. For the same reason, make sure your hands are clean and dry after applying the medication.
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Dosing And Delivery Methods
Bioidentical hormone formulations can be obtained as FDA-approved preparations or from a compounding pharmacy with a physicians prescription.
Various preparations and modes of delivery are available for bioidentical hormones. For example, estradiol is available in FDA-approved oral tablets topical gels, patches, and creams and vaginal rings and suppositories. Bioidentical micronized progesterone is available as FDA-approved oral pills or vaginal gel . Some authors suggest the current evidence indicates that oral micronized progesterone plus topical/transdermal estradiol is the optimal approach to bioidentical HRT .
Importantly, the non-oral route is preferred for bioidentical estradiol. This is because the liver metabolizes orally ingested estradiol before it is available to the rest of the body. This is called the first-pass effect. Also, oral estrogens, but not topical or vaginal estrogens, are associated with increased blood clot risk . Transdermal estradiol, on the other hand, is not associated with increased risk of deep venous thrombosis . Oral progesterone does not increase the risk of blood clots and is an acceptable method of bioidentical progesterone delivery .
To obtain contact information for physicians in your area who are knowledgeable about bioidentical HRT, call 1-800-226-2370.
| Table 1. FDA-Approved Bioidentical Hormone Preparations |
|
Hormone |
A prescription for a peri-menopausal woman might read as follows:
Bioidentical Hrt Vs Traditional Hrt
When it comes to comparing the two natural HRTs, its important to note that bioidentical hormones differ from those in traditional HRT in the sense that theyre chemically identical to those that our bodies naturally produce. Theyre also made from plant oestrogen.
According to bioidentical HRT supporters, its a lot safer because its identical to the hormones that the body produces, but experts believe that the risks of HRT and bioidentical HRT are similar. Compounded bioidentical hormones or compounded bioidentical hormone therapy may have more risks, but there has been no reliable evidence proving that BHRT is more effective when compared to HRT.
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The Goal Of Male To Female Hormone Replacement Therapy:
is to raise estrogen concentration and to lower testosterone concentration to keep both levels in the standard, physiologic female range.
The effects of testosterone, such as coarse body hair and facial hair, are reduced, and female secondary sex characteristics such as breast and hip development, are induced.
This necessitates an inhibition of androgens and the addition of estrogen. The Endocrine Society guidelines for transgender women include estrogens in addition to androgen-lowering medications.
Such a treatment has anticipated physical changes, like slowing of body and facial hair growth, fat redistribution in the female shape, and boosted breast growth.
Natural Alternatives To Hormone Replacement Therapy
What natural alternatives to hormone replacement therapy are there?
Women who decide not to supplement their declining levels of estrogen with prescription hormones may want to choose from a variety of “natural” remedies that may help relieve their menopausal symptoms. Black cohosh root may bring some relief from hot flashes, with potentially fewer side effects than estrogen. Creams made from wild yam extract converted in a lab into a form of progesterone have been promoted by some alternative practitioners for the treatment of hot flashes and vaginal dryness, although little research has been done on their safety or efficacy. These products are sold as an alternative to synthetic progesterone .
Be sure to talk with your doctor before trying these alternative remedies, as some supplements interact with prescription medication or may harm people with certain medical conditions.
Here’s the rundown on alternative treatments:
Soybeans
Experts have long known that Japanese women, who eat large quantities of soy, suffer fewer hot flashes than women in the West, and preliminary studies in the United States support this observation. If you want to try soy, check the grocery or health-food store for foods like tofu, tempeh, miso, soy milk, and roasted soy nuts. Many experts advise against taking soy powder until further research is done.
Black Cohosh
Dong Quai
Herbal Cocktails
Are these treatments safe?
What else can I do?
References
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Natural Alternatives To Hormone Therapy
Protection against uterine cancer vs. the risk of breast cancer. The decision to take estrogen and progesterone supplements can be daunting. In the world of women’s health, it could be the decision of decisions: Should I take hormone replacement therapy? The considerations can be so deep, and the scientific debates so confusing, many women are turning to herbal and food supplements, hoping they will calm the symptoms of menopause while staving off heart disease and osteoporosis.
Though the science is still young, research offers some encouragement for women seeking non-pharmaceutical ways to cut down on mood swings and hot flashes.
Find Ways To Manage Your Stress
Elevated cortisol levels caused by chronic stress may cause symptoms like anxiety, depression, high blood pressure, and weight gain, all of which can be profoundly damaging. Additionally, upregulated cortisol can impact estrogen and testosterone levels, further disrupting hormonal balance. As such, managing stress is crucial for overall bodily health, as well as mental and emotional wellness. Luckily, there are many ways to minimize and cope with both acute and chronic stress, including adding a meditative practice to your daily routine, seeking guidance from a therapist, and investing in regular massage. Using these strategies, you may be able to balance your cortisol levels naturally.
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Diet And Dietary Supplements
Some women find that changing the way they eat, such as eating smaller meals and avoiding triggers is helpful for them.
The effects of specific foods and dietary supplements on menopausal symptoms are not clear. This doesnt mean they wont help, but its important to understand that the evidence supporting their use is limited.
Phytoestrogens: These are estrogen-like substances found in certain plants, such as soy, red clover, and black cohosh. Some women take supplements containing these substances to try to help with symptoms of menopause.
Eating soy foods seems to be safe for breast cancer survivors, although its not clear if it can help relieve menopause symptoms. Women can get higher doses of phytoestrogens in some dietary supplements . However, not enough is known about these supplements to know for sure if they are safe and if they work. If you are considering taking one of these supplements, be sure to talk with your doctor first.
What Is Bioidentical Hormone Therapy
Bioidentical hormones are a form of hormone therapy that has existed since the 1930s and has had resurgence in popularity over the last two decades. Bioidentical hormone replacement therapy has helped thousands of men and women enjoy a healthier, higher quality of life by restoring hormonal balance without the side effects commonly associated with synthetic hormones.
Bioidentical hormones are hormones derived from naturally-occurring sources, such as soy or yams. Bioidentical hormones are compounded in a lab and designed to be structurally indistinguishable from the natural hormones made by the human body. The term, bioidentical, refers to this structural replication. The exact-match replication of bioidentical hormones enhances the effectiveness of the treatment as well as reduces side effects and risks.
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Consultation And Evaluation For Hormone Pellet Therapy
Completion of the Female Hormone Pellet Therapy Consultation will involve full symptom discussion and evaluation, a pelvic ultrasound in our facility, and a panel of laboratories for baseline hormone levels plus other indicated labs. Hormone Pellets may be inserted during the second visit after a discussion of lab and ultrasound results.
Side Effects And Research On Bioidentical Hormone Therapy
A large number of research studies have shown evidence that hormone therapy using bioidentical hormones results in fewer side effects and negative outcomes when compared to synthetic hormones. However, it is important to note that no drug, supplement or herb is 100 percent recommended or safe for every individual. The choice to pursue hormone therapy is not only very personal, but it requires expert administration to ensure safety and effectiveness. It is essential that women who seek hormone therapy choose an expert medical practitioner who has advanced training and pursues continuing education in hormone health, and is one who will take the time to understand their condition and medical history before administering treatment.
More recently, many smaller studies have examined the safety and efficacy of bioidentical hormones3,4,5,6. The results show that for symptoms, such as mood swings, night sweats, hot flashes, anxiety and irritability, bioidentical hormones are safe and effective when administered under the care and supervision of a medical practitioner. Bioidentical hormone therapy carries a lower risk of negative effects on clinical outcomes related to cardiovascular, breast, bone, and brain health than synthetic hormones5,6.
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Are Bioidentical Hormones Safe
The bioidentical hormones that are approved by the FDA have been tested for safety. They have passed the FDA’s strict standards and are safe for people to use. Like all hormone treatments, there are risks involved. You should weigh the pros and cons of even the FDA-approved bioidentical hormones with your healthcare provider.
Do Bioidentical Hormones Really Work
Yes, they work for some people. You will have different results depending on your symptoms and health history. Talk with your healthcare provider about bioidentical hormones and what form may work best for you. In some cases, your healthcare provider may recommend against using bioidentical hormones in favor of a more traditional hormone replacement therapy option.
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Natural Estrogen Hormone Therapy For Women
Hormonal imbalance affects millions of women in the United States. Conditions, such as menopause, thyroid dysfunction, and hypoactive sexual desire disorder are linked to out-of-balance hormones. The symptoms of hormonal imbalance can be life-altering. From mood swings and insomnia to weight gain and hair loss, women suffering from symptoms of hormone imbalance can find relief. Better yet, women can experience better health and a higher quality of life when hormone balance is safely and effectively restored with bio-identical hormone therapy and a comprehensive treatment plan from a qualified practitioner specializing in hormone health and hormone therapy.
Choosing The Best Type Of Estrogen Therapy
When deciding what type of estrogen therapy to get, work closely with your doctor. While oral estrogen has been around for a long time and is well studied, some modes of taking hormone therapy are not. They may have lower risks or different risks that we dont know about yet. Your doctor should be up to date on the latest research.
Right now, the full risks of hormone therapy are unclear. So if you do decide to get ERT, experts generally recommend that you get it at the lowest dose for the shortest time possible. Talk to your doctor about how long you should expect to take ERT and how you can limit your risks.
ACP Medicine web site: Menopause.
Canonico M et al, Circulation, Feb. 20, 2007 vol 115: pp 840-845.
MedicineNet web site: Hormone Creams: Safe and Effective?
National Cancer Institute web site: How to Deal with Surgical Menopause.
National Institutes of Health web site: Facts About Menopausal Hormone Therapy.
National Institutes of Health Medline Plus web site: Estrogen,Estrogen Vaginal,Estradiol Topical,Estradiol Transdermal.
Practice Committee of the American Society for Reproductive Medicine, Fertility and Sterility, November 2006 vol 86: pp S75-S88.
National Womens Health information Center: Menopause and Menopause Treatments. WebMD Medical Reference: Estrogen Replacement Therapy,Low Dose Estrogen for Dryness and Atrophy.
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Natural Remedies For Hormonal Imbalances In Females: Do They Really Work
Hormone imbalance is a big buzzword in the womens health and wellness space today. The trouble is, many people dont understand what actually causes a hormone imbalanceor how to treat one properly. At the same time, natural remedies for hormonal imbalances in females are becoming increasingly popular, and women tend to seek these remedies because theyre marketed as being safer and having fewer side effects than conventional medicine. But the truth is, no one really knows whether most of these home cures are effective or safe for all women. And even if a natural remedy works for some, there is no guarantee it will work for you.
Before seeking natural or over-the-counter remedies for the symptoms you experience, its important that you speak with a hormone health professional to determine whether you are experiencing an imbalance and identify how to address your symptoms. Get your hormones tested in addition to a full physical exam, and discuss the results with a qualified hormone practitioner. If you are found to have a hormone imbalance, theyll be able to help you identify which treatment options may be best for your body and, if appropriate, provide guidance on how to best integrate natural remedies in your treatment plan.
Claim : Compounded Bht Has A Better Effect On Bones Than Fda
Among the claims in favor of CBHT for better bone health are the scientifically based observations about the benefits of estrogen and testosterone in preventing bone loss, as well as the suggestion of progesterone as an agent that can assist in rebuilding lost bone. These claims are an extrapolation of data derived from many peer-reviewed studies using standard doses of manufactured estrogen and testosterone that have shown a beneficial effect of estrogen in preventing postmenopausal bone loss.39 The WHI is the only randomized, controlled study demonstrating reduced hip fracture risk with E+P therapy.40 None of these claims has been substantiated directly with CBHT or correlated with the wide variety of CBHT preparations in use. Although credible by inference with the class of therapy , the claims that CBHT prevents bone loss or rebuilds lost bone have not been proven.
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