Wednesday, September 28, 2022

What Testosterone Should I Take

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The Healthy Testosterone Reference Range

How Much Testosterone Should I Take?

Depending on the lab, the healthy range of natural Testosterone production could be as low as 240 ng/dL on the bottom, and 1000 ng/dL on the high end.

Some labs are even worse.

It doesnt take a rocket scientist to realize that a Testosterone level 4x higher will not equate to the same quality of life, muscle building potential, etc.

However, 90% of doctors still are so far behind the curve that they truly believe that a 250 ng/dL Testosterone level is just as good as a 1000 ng/dL Testosterone level.

The History Of Testosterone

Imagine sitting at a scientific conference in Paris, on June 1, 1889, when your 72-year old colleague, Dr. Charles Brown-Sequard, describes miraculous improvements in his physical and mental stamina, and even the arc of his urine flow ever since first injecting himself with a concoction of blood, semen, and testicular fluid he had extracted from the testicles of dogs and guinea pigs. Gross…and a bit creepy, right? Not in 1889, apparently.

Brown-Sequard’s “Elixir of Life” would be prescribed by over 12,000 physicians by the end of that same year. However, it wasn’t until 1935 that the hormone responsible for these remarkable anti-aging, energy, and performance-enhancing benefits would get its name: testosterone. That same year, both Swiss researcher Leopold Ruzicka and German researcher Adolf Butenandt would discover how to synthesize it for commercialization, and later be jointly awarded the Nobel Prize for chemistry for the achievement.

Ever since then, the king of hormones has been one of the most controversial and sought-after substances in health, fitness, and sport. But fortunately for Fido, dogs no longer have to donate the family jewels in your quest for the fountain of youth and weight-room domination.

How Much Testosterone Enanthate Per Week

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The Point Of Using A Testosterone Base

One of the most misunderstood concepts in our community is the Testosterone base.

I had heard for years that Testosterone needs to be a base for every single steroid cycle.

No matter what, you needed to have Testosterone in there.

Logically, this makes sense on the surface.

We naturally produce Testosterone, so if you shut down your hypothalamicpituitarygonadal axis with exogenous steroids then you would need to replace your Testosterone production with exogenous Testosterone.

That was as far as anyone would explain the point of a Test base though, and for several years I accepted that as best practice.

At a higher level, despite the fact that a Test base is still something that will be beneficial for the vast majority of AAS users, it is important to understand why you are injecting a steroid to begin with.

Why exactly is an oral-only cycle a poor choice at a higher level than your gym bro telling you if you don’t use Test you will get f*cked up!

Well, the main reason you need Testosterone is not just to activate androgen receptors and transcribe anabolic and androgenic effects in tissues in the body, but also it is to aromatize into a sufficient amount of Estrogen to fulfill a myriad of other physiological functions.

Little consideration was given for the androgen to Estrogen ratio in the body, the fat loss and growth factor inhibiting effect unnecessarily lowering Estrogen can have, or the massive impact Estrogen has on lipid modulation.

Sexual Function Physical Function Vitality

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Results from the first three trials were reported in February 2016 in the New England Journal of Medicine.

Inclusion in the Sexual Function Trial required participants to have a decrease in libido along with a sexual partner willing to have intercourse two times a month.

Inclusion in the Physical Function Trial required participants to have slow gait speed, difficulty walking, and difficulty climbing stairs. Men who couldnt walk, had severe arthritis, or had severe neuromuscular disease were excluded.

Inclusion in the Vitality Trial required participants to have fatigue and low vitality.

Raising testosterone levels from low to a normal range improved sexual function modestly as well as mood and depressive symptoms. However, testosterone supplementation didnt improve walking ability or vitality.

Overall, the researchers suggest that there werent enough participants to draw definitive conclusions in these three trials.

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Appendix D: Testosterone Therapy And The Risk Of Major Adverse Cardiac Events

Given the conflicting nature of the evidence, the Panel cannot definitively state that there is an association between testosterone therapy and subsequent MACE events nor can it be stated definitely that testosterone therapy is associated with reduced incidence of MACE. However, the FDA added a warning to testosterone product labeling after reviewing five observational studies and two meta-analyses of RCTs that examined the effects of testosterone therapy on MACE. Two of the trials and one meta-analysis pointed to an increased risk of cardiovascular events,363, 364, 366 two revealed no cardiovascular risk,233, 367 and one was neutral with respect to risk.373 The Corona meta-analysis,372 which showed that there was no increased risk of cardiovascular events, was not officially reviewed but was taken into consideration in the final analysis. Although the committee reviewing the evidence concluded that there was not enough data to definitively state that testosterone therapy posed a significant cardiovascular risk, the FDA nonetheless required testosterone product manufacturers to add information to the labeling about a possible increased risk of myocardial infarction and cerebrovascular accidents in patients using testosterone therapy.

Venothrombolic event

Warnings For People With Certain Health Conditions

For people with liver problems: This medication can cause liver damage. This may lead to serious liver disease. If you have liver disease, this drug may also cause salt and water retention. This may make your liver disease worse.

For people with heart problems: If you have heart disease, this drug may cause salt and water retention. Both the medication and the salt and water retention can make your conditions worse. If you have a history of heart attack or heart disease, ask your doctor whether this drug is safe for you.

For people with kidney problems: If you have kidney problems or a history of kidney disease, this drug may cause salt and water retention. Both the medication and salt and water retention can make your conditions worse.

For people with breast cancer: You shouldnt take this drug if youre a man with breast cancer. This medication may make your disease worse.

For people with prostate cancer: You shouldnt take this drug if you have prostate cancer. Testosterone cypionate may make your disease worse.

For people with sleep apnea : If you have sleep apnea, ask your doctor whether this drug is safe for you. This medication may make this condition worse. You may wake up more often at night, which may cause you to be more tired during the day.

For people with polycythemia : This drug may significantly increase your red blood cell count and make your condition worse. You shouldnt use this drug if your hematocrit is above 54%.

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High Dose Trt Vs Low Dose Trt

There are constant arguments about what the optimal replacement dose of Testosterone is.

There’s a small camp of guys who believe that 10 milligrams of Testosterone Propionate per day is ideal for most men, and I’m inclined to agree with them far more than the guys who believe that dosages as high as 200 mg per week are necessary.

This will of course vary depending on a variety of factors, but typically 10 mg of Testosterone Propionate per day will put an individual at top end of the Testosterone therapeutic range.

I find that when men talk about ideal dosages being closer to 125 150 200 mg per week, the ester weight often isn’t taken into account , and they are often individuals who administer large dosages at once, let their levels spike way above the therapeutic limit up to supraphysiological levels for a few days, and slowly crash underneath that until their next shot.

If you get your blood drawn during a trough and the results show that you have a 850 ng/dL Testosterone level, you may not be accounting for the fact that right after you administered your fat weekly dosage, your levels probably skyrocketed upwards of 1500 ng/dL.

I found this statistic very interesting as 50 milligrams a week really is not much whatsoever in contrast to what most guys are injecting weekly believing they are just replacing their natural production.

What Are The Risks Of Testosterone Therapy

How Often Should I Inject? (Testosterone Replacement Therapy)

A relatively small number of men experience immediate side effects of testosterone treatment, such as acne, disturbed breathing while sleeping, breast swelling or tenderness, or swelling in the ankles. Doctors also watch out for high red blood cell counts, which could increase the risk of clotting.

Men on long-term using forms of testosterone therapy long term appear to have a higher risk of cardiovascular problems, like heart attacks, strokes, and deaths from heart disease. For example, in 2010, researchers halted the Testosterone in Older Men study when early results showed that men on testosterone replacement therapy had noticeably more heart problems. “In older men, theoretical cardiac side effects become a little more immediate,” Dr. Pallais says.

Some physicians also have a lingering concern that testosterone therapy could stimulate the growth of prostate cancer cells. As with the hypothetical cardiac risks, the evidence is mixed. But because prostate cancer is so common, doctors tend to be leery of prescribing testosterone to men who may be at risk.

So, keep risks in mind when considering testosterone therapy or other therapies . “I frequently discourage it, particularly if the man has borderline levels,” Dr. Pallais says.

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Exercise And Testosterone The Complete Guide

This guide covers everything youve ever wanted to know about how exercise and testosterone are related. From weight lifting while on Testosterone Replacement Therapy to how High Intensity Interval Training helps those who suffer from borderline Low T and more, this guide will walk you through each topic and help you understand whats true, whats not so true, and what to do next.

Use the table of contents to navigate to the information youre most interested in, or simply start reading.

How Much Time Does Testosterone Replacement Therapy Take To Start Working

Testosterone replacement therapy can take several months to fully resolve symptoms, but you might start to feel certain benefits much sooner. The following effects are some that you can expect to see within a few weeks of beginning therapy. As you read, however, it is also important to remember that every body is different. That means there is no exact time frame that applies to everyone. Ultimately, consult your doctor if you are concerned that TRT is taking too long.

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Medical Testosterone Cypionate Dosage

Within the field of medicine, prescription guidelines for Testosterone Cypionate doses for the purpose of adult male androgen deficiency is determined to be 50 400mg administered once every 2 4 weeks. The specific dose will always depend on the individual in question, and how much Testosterone Cypionate is required in order to sufficiently raise the persons Testosterone level back up to a normal range. This is most usually determined through blood tests and a doctors reccomendations.

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What Other Drugs Interact With Testosterone

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

Serious interactions of testosterone include:

Moderate interactions of testosterone include:

  • axitinib
  • ponatinib

Testosterone has moderate interactions with at least 41 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Side Effects From Testosterone Enanthate Cycle

Compared with other steroid compounds, Testosterone enanthate can be thought to have only mild side effects risks as is the case with other testosterone esters.

This is a hormone that the male body is naturally used to and it is just the higher dose for bodybuilding and performance purposes that introduce possible adverse effects as the effect of testosterone in the body is amplified.

Testosterone naturally aromatizes at a relatively mild level compared with other steroids, and this is where we see the side effects developing as a result of estrogen conversion.

The higher the dosage, the greater the estrogen related effects will be. Individual reactions to the steroid will also vary which is why beginners should always use Testosterone Enanthate as a sole compound in a cycle to gauge side effects.

Potential side effect risks include all the familiar adverse effects such as possible hair loss and acne, gyno, high blood pressure and in some people nausea and headaches can occur.

Water retention, when left to advance, can lead to high blood pressure and this is the more serious aspect of side effects you need to think about.

It will also cause your gains to not be as made of as much solid muscle as youd like, and these mass gains can dissipate following a cycle if water retention is high therefore controlling estrogen side effects when using Testosterone Enanthate at higher doses is important not only for your health but for your longer term results.

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Is It Safe To Take Testosterone Supplements

Weve already discussed the potential side effects of testosterone boosters, and weve told you that there are more serious, though rare effects as well. All of this depends on how much testosterone youre taking, how long youre taking it, and especially how much of it your body lacks.

As the FDA has warned, these potentially harmful side effects can occur because these boosters are sometimes easily abused. Thats why you need to be careful with the dosage and the period of use.

How Does Testosterone Affect Body Fat Weight And Body Composition

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Low testosterone in men increases fat and weight gain, reduces caloric expenditure, increases the prevalence of blood glucose disorders and insulin insensitivity, and otherwise negatively affects metabolic control. In women, unusually high testosterone has many of the same negative effects.

Collectively and in both sexes, testosterone acts directly within your central nervous system to regulate metabolism, affecting how well your body burns calories and maintains healthy blood glucose levels.

For example, when 200 milligrams of prescription testosterone enanthate was injected just once per week for six months, in men ages 21-37 that were healthy but didn’t exercise, testosterone levels increased by 91.1 percent. Lean mass concurrently increased by 9.6 percent, and body fat reduced by 16.2 percent.

The results of 59 studies involving more than 5,000 subjects concluded that younger adults realize the greatest decrease in blood glucose in response to using prescription testosterone, as do adults with metabolic disorders. The studies also concluded that supplementing with testosterone significantly increases lean muscle mass, reduces body fat, and makes the body more sensitive to insulin. Data from these same studies suggested that with no change to exercise or diet, just adding supplemental testosterone can reduce body weight by up to 11.5 pounds in two years.

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When Should You Consider Testosterone Treatment For Ed

If youve had trouble having erections for three months, talk to your doctor. He or she will ask about all your symptoms and give you a physical exam. Symptoms of low testosterone can include less of a sex drive, loss of body hair, breast growth, needing to shave less often, a drop in muscle size and strength, and bones that break more easily.

If you have some of these symptoms, your doctor may have you get a blood test to measure your testosterone levels. The blood test should be done more than once. It is best to do it in the morning when testosterone levels are highest.

If the tests show that you have low testosterone levels, your doctor should look for possible causes. For example, the low levels might be caused by a problem in the pituitary glands.

If no other cause is found, you can try testosterone treatment.

This report is for you to use when talking with your health-care provider. It is not a substitute for medical advice and treatment. Use of this report is at your own risk.

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