Testosterone Therapy Often Makes Them Feel Better
There appears to be little argument to the fact that men with below normal testosterone levels experience a benefit from testosterone gel and at times multiple benefits.
The biggest benefit is usually in how men feel, Anawalt says. For hypogonadal men, testosterone therapy often makes them feel better. Many men will report improved sexual function and pleasure and some will report improved energy and vitality.
The Testosterone Trials proved these outcomes. The most striking and consistent improvements were in sexual function, Bhasin says. Men who received testosterone reported better sexual function than those in the placebo group. This included more sexual activity, improved sexual desire, and increased erectile function.
In the Physical Function Trial, the mens six-minute walking distance was measured. There was some improvement in the walking speed in all men who were included in the trial. The percent of men whose six-minute walking distance increased by at least 50 m did not differ significantly between the two groups. However, when men were asked whether their walking ability was better, they perceived that it had improved, according to Bhasin.
What Side Effects Are Possible With This Medication
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- prostate disorders
- skin irritation, redness, or rash where applied
- sleep disturbances caused by breathing problems
- weight gain
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- breast soreness or enlargement
- signs of depression
- high blood pressure
- increased or irregular heart rate
- problems with urination
- signs of a blood clot in the arm or leg or lungs
- symptoms of liver problems
Stop taking the medication and seek immediate medical attention if any of the following occur:
Financial And Insurance Assistance
If you need financial support to pay for Natesto, or if you need help understanding your insurance coverage, help is available.
Acerus Pharmaceuticals Corporation, the distributor of Natesto, offers programs called Natesto at Home and the Natesto Savings Program. For more information and to find out if youre eligible for support, visit the programs website. You can also call 877-300-1833 for Natesto at Home and 855-390-0162 for the Natesto Savings Program.
For more information, check out this article to learn more about saving money on prescriptions.
Drug Forms And Strengths
Natesto comes as an intranasal gel . It contains the active drug testosterone.
The gel comes in a metered dose pump . Each full press of the pump contains 5.5 milligrams of testosterone in 0.122 grams of gel. The pump can be used 60 times and contains a total of 11 g of testosterone. This is about a 10-day supply.
Note: Natesto isnt a nasal spray. You apply the gel only on the insides of your nostrils, where it can be absorbed by your body.
How To Take Natesto
Make sure to take Natesto according to your doctors instructions.
Natesto comes as an intranasal gel, which is a gel that you apply to the inside of your nostrils. The gel comes in a metered dose pump .
Typically, youll place one full press of the Natesto pump into each nostril, three times per day. Aim the pump away from the center of your nose, so that the tip gently touches the inside of your nostril.
The Natesto pump can be used 60 times, which typically is a 10-day supply. Before you start using a new pump, you should prime it according to the manufacturers directions. For these directions or for more detailed instructions about how to take Natesto, see its patient information. You can also talk with your doctor or pharmacist.
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What Do I Need To Tell My Doctor Before I Take Testosterone Gel
- If you have an allergy to testosterone or any other part of testosterone gel.
- If you are allergic to testosterone gel any part of testosterone gel or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you are male and have breast or prostate cancer.
- If you have any of these health problems: Heart disease, kidney disease, or liver disease.
- If you are a woman. This medicine is not approved for use in women. If you are a woman using testosterone gel, talk with your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding.
- If the patient is a child. Do not give testosterone gel to a child.
This is not a list of all drugs or health problems that interact with testosterone gel.
Tell your doctor and pharmacist about all of your drugs and health problems. You must check to make sure that it is safe for you to take testosterone gel with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Testosterone Assays Interpretation Of Results
Although it is not mandatory to perform testosterone level estimation prior to or for monitoring treatment, it can be useful. A low FAI < 1.0% in women with symptoms of low sexual desire and arousal, supports the use of testosterone supplementation. Repeat estimation at the 2-3 month follow up visit can be performed to demonstrate if there has been an increase in levels, though clinical response is of paramount importance. It is also useful to demonstrate that values are being maintained within the female physiological range, typically < 5%, thus making androgenic side effects less likely.
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Hemoglobin Hematocrit Clinical Chemistry
Serum hemoglobin and hematocrit concentrations increased with T gel replacement, compared with month 0 and month 6 and then plateaued at 12 months after initiation of treatment . The increases in hematocrit and hemoglobin were statistically significant in both younger and older subjects . At 12 and 18 months after treatment, the increase in hemoglobin and hematocrit concentrations was higher in the group applying 10 g T gel per day , compared with those applying less T gel. The increases were not different between the groups at months 30 and 36. Fourteen patients had hemoglobin over 18 g/dl or hematocrit greater than 56% at some time during the study. The T gel dose was reduced or temporarily discontinued in these patients. Serum total and low-density lipoprotein cholesterol levels did not change significantly throughout the T gel treatment period. Serum high-density lipoprotein showed a very small but statistically significant increase across time with T gel. The increase was not clinically relevant. Mean serum creatinine was statistically increased across the treatment period. The mean increase varied from 0.08 to 0.20 mg/dl. Serum total bilirubin also showed a small but significant increase with T gel treatment that was not considered to be clinically significant. There were no significant changes in serum liver enzymes or other clinical chemistry parameters.
Why Is This Medication Prescribed
Testosterone topical is used to treat the symptoms of low testosterone in adult men who have hypogonadism . Testosterone is used only for men with low testosterone levels caused by certain medical conditions, including disorders of the testicles, pituitary gland , or hypothalamus that cause hypogonadism. Your doctor will order certain tests to check your testosterone levels to see if they are low before you begin to use testosterone topical. Testosterone should not be used to treat the symptoms of low testosterone in men who have low testosterone due to aging . Testosterone is in a class of medications called androgenic hormones. Testosterone is a hormone produced by the body that contributes to the growth, development, and functioning of the male sexual organs and typical male characteristics. Testosterone topical works by replacing the testosterone that is normally produced by the body.
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How Should This Medicine Be Used
Topical testosterone comes as a gel and solution to apply to the skin. It is usually applied once a day. It is best to apply testosterone gel or solution in the morning. To help you remember to apply testosterone topical, apply it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use testosterone topical exactly as directed. Do not apply more or less of it or apply it more often than prescribed by your doctor.
Testosterone topical products are manufactured differently and are used in slightly different ways. Be sure that you know which topical brand you are using and how and where you should apply it. Read the manufacturer’s patient information that came with your topical testosterone product carefully.
If you usually take a bath or shower in the morning, be sure to take your bath or shower before you apply testosterone topical products. Read the manufacturer’s patient information about your topical testosterone product for information about when you can wash, shower, bath, or swim after you apply the medication.
You should not apply any testosterone topical products to your penis or scrotum or to skin that has sores, cuts, or irritation.
Be careful not to get testosterone topical in your eyes. If you do get testosterone topical in your eyes, wash them right away with warm, clean water. Call a doctor if your eyes become irritated.
How Long Does Testosterone Replacement Therapy Take To Work
In a general sense, effects on quality of life tend to start showing up in the first few weeks. Improvement in mood and energy can begin to manifest within 34 weeks, but maximum benefits can take longer.
Two studies using the widely accepted Hamilton Depression Rating Scale found an improvement in patients on TRT. The first, , showed an improvement in symptoms of depression in men in six weeks. The second, , showed similar improvement occurred after eight weeks.
Increases in sociability, decrease in anxiety, increase in concentration, and self-confidence) began to appear in about three weeks. Men reported a decrease in fatigue and listlessness in approximately 4-6 weeks.
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What Are The Currently Available Options
The available products keep changing for commercial reasons this section of the factsheet in particular will be updated regularly to maintain its relevance. An audit will be carried out to assess what preparations are available in different areas of the UK to make this guidance as realistic as possible.
Note 1: When treating low sexual desire /arousal it is also important that urogenital tissues are adequately estrogenised in women with vulvovaginal atrophy / genitourinary syndrome of the menopause e.g. through use of vaginal estrogen, to avoid dyspareunia.
Note 2: Although the NICE NG23 guideline recommends that systemic HRT should be prescribed before a trial of testosterone, there are trial data in women with HSDD which indicate that testosterone used without systemic estrogen, is equally effective and safe.
Note 3: Tibolone is weakly androgenic, progestogenic and estrogenic although it is an option for women with low sexual desire it is not sufficiently androgenic nor estrogenic in many women. The progestogenic effect is not required in hysterectomised women and may cause unnecessary adverse effects.
Note 4: Compounded bioidentical testosterone preparations are not recommended by the regulatory authorities or the menopause societies.
1. AndroFeme is not currently available in the NHS and is being imported from Western Australia by special license from the MHRA. Designed for female usage.
What Is The Impact Of Testosterone Deficiency
This can lead to a number of distressing sexual symptoms such as low sexual desire, arousal and orgasm. Other contributory factors which should be taken into account when assessing women with these symptoms include psychosexual, physical, iatrogenic and environmental. Testosterone deficiency can also contribute to a reduction in general quality of life, tiredness, depression, headaches, cognitive problems, osteoporosis and sarcopenia.
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Testosterone Topical May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:
- breast enlargement and/or pain
- difficulty breathing, especially during sleep
- erections that happen too often or that last too long
- difficulty urinating, weak urine flow, frequent urination, sudden need to urinate right away
- yellowing of the skin or eyes
Testosterone topical may cause a decrease in the number of sperm produced, especially if it is used at high doses. Talk to your doctor about the risks of using this medication if you are a man and would like to have children.
Testosterone may increase the risk of developing prostate cancer. Talk to your doctor about the risks of using this medication.
Testosterone topical may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .
Is It Available On The Nhs
NICE Guidance on menopause states that testosterone can be considered for those that need it .
Testosterone can be prescribed on the NHS if the prescriber is familiar with it and is willing to prescribe it off licence. Some prefer not to take this decision and refer to a specialist for advice before prescribing. Other GPs will have prescribing restrictions which mean they are not able to offer it.
Testosterone Therapy: Months Four And Five
As you enter month four of being on testosterone replacement and complete month five, you will hardly recognize the person you were when you started your program. In months four and five, you will see the most significant before and after results of your T-therapy. When you like in the mirror, you will see a trimmer, slimmer, more youthful version of yourself. After five months of testosterone therapy, you will have significantly more energy, your muscles and bones will be stronger, your body fat will be considerably reduced, and your sex life will probably be the best it has been in years!
How Soon Can I Expect Results
Everybody is different and the amount of time it takes to notice changes in your body greatly varies from individual to individual.Hormonal therapy cant be speeded up, its like going through puberty.Increasing the testosterone blockers dosage wont accelerate the changes.
Below are effects and the amount of time you should expect to see results.1.Breast growth can start after 3-6 months. The maximum results can be expected between 2-3 years
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A Year After Treatment: What Can I Expect
After a year of TRT, men tend to experience the full benefits of treatment.
Patients mental state is much more balanced and their brains are able to think much clearer. They are much more positive, happier, and see an increase in their overall well-being.
Their sleep habits are fully restored. This also boosts morale and greater feelings of enjoyment.
Mens sex lives reach a peak, and they continue to experience great levels of sexual intimacy. Not only does sexual desire increase, but their physical attractiveness continues to develop.
Men will see continued growth in their muscle strength and have much stronger bones.
Their lean body mass is much more developed than it was at the 3-month mark. This leads to a reduction in overall body fat.
Prostate levels do not continue to grow after its initial spike. They have leveled out at this point in treatment.
Blood pressure, cholesterol, and triglyceride levels are also at a healthy state. Lastly, patients will see increased red blood cell formation.
Response To Testosterone Therapy And Duration Of Use
The loss of sexual desire is complex and may have hormonal, medical, psychosexual and psychosocial aetiologies. In clinical trials of women with HSDD, approximately 2/3 of women responded positively to testosterone therapy . The trials demonstrated that response may not be immediate, taking 8-12 weeks in some instances for the effect to become clinically significant. It is therefore advised that treatment should trialled for a minimum of 3 months and maximally for 6 months before being discontinued due to lack of efficacy. Duration of use should be individualised and evaluated at least on an annual basis, weighing up pros and cons according to benefits and risks, as per HRT advice from all menopause societies.
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So How Soon Will I See Results
It isnt uncommon for patients to feel impatient waiting to see results. Days? Weeks? Months? The trouble is, the signs and symptoms of low testosterone vary from patient to patient, as do the treatments and the expected time it will take for results to be seen.
For most men, treatment is a gradual process with no definitive timeframe. With that in mind, youre most likely to record positive results within the first 3 to 6 months, though a majority of men report an easing of symptoms and a return to health much sooner. Often as little as 3 to 6 weeks.
Based on our experience here at Genesys Mens Health, weve found that certain symptoms respond to treatment quicker than others. Its not uncommon for your libido and sex drive to return to healthy levels within 3 weeks, while other symptoms such as chronic illness or obesity may take a little longer.
According to patient testimonials and relevant research, general timeframes are: