Scientists Pinpoint Dosage Of Melatonin For Insomnia
MIT researchers reported in the October issue of the Journal of Clinical Endocrinology & Metabolism that doses of melatonin, a pineal hormone that is secreted by humans at night, can help older adult insomniacs obtain a good night’s sleep.
During the study, Richard Wurtman, the Cecil H. Green Distinguished Professor and program director of the Clinical Research Center, and other MIT researchers examined the ability of similar doses to restore nighttime melatonin levels and sleep efficiency in adults over age 50.
Two groups of subjects were involved in the study–one group who slept normally and another who experienced insomnia. Each subject received one-week doses of either a placebo or three different doses of melatonin in randomized order. Each different treatment was separated by a one-week “wash-out period.”
“According to our research, the physiological dose of melatonin of about 0.3 milligrams restores sleep in adults over the age of 50,” said Wurtman, lead investigator in the study. “The adults who would normally wake up during the second and third thirds of the night were able to sleep through the night with the 0.3 milligram dosage.”
The MIT scientists, who included Irina Zhdanova, former principal research scientist in the Department of Brain and Cognitive Sciences, also showed that low doses of melatonin affect sleep in young individuals and can help children with a debilitating neurological disorder called Angelman syndrome to sleep though the night.
When Should You Take Melatonin
When it comes to when you should actually take melatonin supplements, many people assume that it is appropriate to take them right before bedtime. But this may not actually be the most ideal scenario.
Timing is key in terms of the effectiveness of your melatonin supplements, and taking them too close to your desired time of sleep may leave you disappointed. Instead of taking your supplements right when you are hoping to fall asleep, the right time may actually vary depending on your preferred sleeping schedule.
Someone who tends to go to sleep after midnight but who wants to be asleep by around 11 p.m. may be best satisfied by taking melatonin at 6 p.m., and someone who goes to bed around 8 p.m. but rises early, at around 4a.m., may want to take their melatonin in the afternoon.
The reason why you may want to take your melatonin a few hours before you head to bed is because melatonin actually takes a little while to start working in your body.
How To Use Melatonin For Jet Lag
Jet lag is an air travel problem that causes difficulty in sleeping, fatigue, trouble concentrating, constipation, and other symptoms. Jet lag is much more likely if you cross over several time zones, and can worsen the more time zones you cross.
Effective starting doses for jet lag range from 0.3 to 0.5 mg. Smaller doses may work for some while others may need a higher dose. It may be more difficult to fly east, when time is lost, rather than to fly west, when you gain it back. High doses, such as 20 mg pills are available for purchase on the Internet, but such high doses are not normally recommended or needed, and may greatly increase side effects.
- Eastbound: If you are traveling east, say from the US to Europe, take melatonin after dark, 30 minutes before bedtime in the new time zone or if you are on the plane. Then take it for the next 4 nights in the new time zone, after dark, 30 minutes before bedtime. If you are still feeling drowsy the day after using this medication, try a lower dose.
- Westbound: If you are heading west, for example, from the US to Australia, a dose is not needed for your first travel night, but you then may take it for the next 4 nights in the new time zone, after dark, 30 minutes before bedtime. Melatonin may not always be needed for westbound travel.
Given enough time , jet lag will usually resolve on its own, but this is not always optimal when traveling.
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How Effective Is Melatonin For Sleep Problems In Children
The overall effects of melatonin for children include falling asleep more quickly and an increase in sleep time. Like all medicines used to help children fall asleep, there is fairly limited information available. This means that most studies have small groups followed for short periods of time. Furthermore, melatonin not regulated as a pharmaceutical in the U.S. Thus, there is no large pharmaceutical company bankrolling larger and long-term studies . Rather it is regulated as a food supplement by the FDA. For a terrific review, including dosing recommendations, I highly recommend this article by Bruni et al.
How Often Are Children Using Melatonin
Its hard to know for sure. An article the New York Times, Parents Are Relying on Melatonin to Help Their Kids Sleep. Should They?, noted that melatonin sales overall had increased by 87% in the year prior to March 2020. The Times conducted a survey of 933 parents with children under age 18. One third had a history of sleep difficulties in the past year. Over half the parents reported giving melatonin to their children at one time.
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Bottom Line: Pros And Cons
Benefits:
- Widely available in the U.S. over-the-counter without a prescription
- Short-term use is relatively safe with little evidence of toxicity
- Inexpensive product with generics or store brands available
- Lower dose and orally-dissolvable products for children are available
- Comes in a variety of dosage forms and doses
Downsides:
- Not approved for any uses by the FDA
- Quality of some products cannot always be assured
- Studies for less common uses are not consistent
- Doses tend to vary between patients always ask a medical professional for dosing advice in children
- Effective lower doses are not always commercially available
- Higher doses used over a prolonged period may lead to rebound insomnia and are not well studied.
Melatonin For Children A Guide For Parents
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Pediatricians frequently recommend melatonin for children with sleep problems, or parents might try it themselves. However, the proper use of melatonin is frequently misunderstood. Here is a guide for parents and pediatricians to decide if a child should try it, and to understand how it should be used.
A common thread I find in children coming to Sleep Clinic is that many or all of them have been on melatonin at some point, or are taking it currently. Melatonin is an important tool in the treatment of sleep disorders in children, and because it is naturally derived, there is a widespread perception that it is safe. However, I have become concerned by the frequency of its use, especially in an unsupervised way.
Melatonin sales have doubled in the past ten years, increasing from $90 million in 2007 to $260 million in 2012. Melatonin for children products are being marketed aggressively. I worry that the widespread availability of melatonin has led to some parents using it as a shortcut to good sleep practices. An article in the Wall Street Journal , quoted a fathers review on Amazon:
OK, yes, as parents my wife and I should do a better job starting the bedtime routine earlier, turning off the TV earlier, limiting sweets, etc., etc. Well, for whatever reason, this is not our strong suit. This 1 mg light dosage of melatonin is very helpful winding our kids down and getting them ready for bed.
NOTE:
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When To Talk To Your Doctor About Melatonin
To ensure safe usage, it is always a good idea to consult your doctor before taking any over-the-counter sleep aid, including melatonin. They know your personal medical history and can best advise you on the appropriate melatonin dosage for your needs. They will also know whether melatonin might interact with any other medications you may currently be taking.
Certain health conditions and medications may increase your risk of side effects when taking melatonin. If you take any of the following medications, be sure to talk to your doctor before taking melatonin:
- Pregnant or breastfeeding women
- Shift workers
The research into melatonins potential benefits and use cases is still evolving, and its long-term effects are still unknown. For many people, melatonin offers mild improvements to sleep problems when used on a short-term basis. For others, it may cause side effects or not impact sleep at all.
If you find your sleep problems persist after trying melatonin, it may be time to talk to a doctor. They can recommend other strategies for improving your sleep, such as better sleep hygiene, changes to diet and exercise, or cognitive-behavioral therapy for insomnia. They can also evaluate other possible causes for your sleep problems.
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What Are Melatonins Side Effects On Kids
Potential, though mild, side effects of melatonin use in children include agitation, headache, dizziness and drowsiness. While it is not known for sure and more research on the long term use of melatonin in children is needed, its important to remember that melatonin is a hormone, and, as such, there is a possibility that it may affect hormonal development, including puberty and menstrual cycles.2
The Bottom Line
If your child occasionally has trouble falling asleep, instilling better sleep habits and routines might be in order. But if your child experiences significant difficulty falling asleep, melatonin might benefit, especially when its used in combination with behavioral interventions and healthy sleep practices.5
Most importantly, talk with your childs pediatrician before giving them melatonin to make sure its right for them, to understand the proper dosage, and to rule out any underlying health issues.
Continue to check back on the Nature Madeblog for the latest science-backed articles to help you take ownership of your health.
This information is only for educational purposes and is not medical advice or intended as a recommendation of any specific products. Consult your health care provider for more information.
References
1 Mayo Clinic. Melatonin. March 30, 2018. Accessed on: September 23, 2020.
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What Is The Best Dose Of Melatonin
05/21/2021 | 10 min. read
Healthy Directions Staff Editor
Melatonin is widely used in order to improve sleep quality, and may help people who have a hard time falling asleep or even staying in bed.
If you are considering using melatonin supplements to improve your quality of rest due to sleep disturbances, melatonin may be an effective way to help you get a good nights rest.
But before you take melatonin supplements, there are a few things to help you get the most of it.
Melatonin is a hormone that gets produced by your brain in response to darkness, and it works to help with your sleep and circadian rhythm, which is basically your internal clock.
Because melatonin is produced when your body recognizes that your surroundings are dark, being exposed to lights at nighttime can interfere with your melatonin production and thus may also interfere with your ability to get a good nights rest.
Melatonin supplements are not an automatic fix — it is important to ensure your bedtime behaviors are conducive to melatonin production so that your supplements can properly do their job.
What Happens If I Miss A Dose
If you miss taking a dose there is no cause for concern, but melatonin may impair your thinking and reaction time. If you will be driving or doing any hazardous activity, skip your dose as melatonin can cause drowsiness.
Otherwise, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine or double your dose to make up the missed medication.
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What Is The Correct Melatonin Dosage For Me
The recommended dose of melatonin is the lowest dose that can help your sleep quantity and quality without causing side effects. While the right dose varies from one person to another, between 0.5 milligrams and 5 milligrams once daily is the typical starting dose for adults. Research indicates that taking doses of 10 milligrams or higher may cause side effects. The maximum recommended dose of melatonin is 10 milligrams.
Several factors, such as age, body weight, and sensitivity to melatonin may affect the recommended dosage. The dose also depends on the type and severity of the sleep problem. Certain drugs may also affect the way melatonin is metabolized. Speak to your physician if you are taking other medications before starting melatonin.
When using melatonin for the first time, begin at a low dose and adjust in increments of 1 milligram, depending on response. Generally, the optimum time to take melatonin is one to two hours before bedtime. There’s some evidence of tolerance with melatonin use, so it’s not recommended to increase the dose over time after reaching the lowest effective dose.
Melatonin For Kids: Dosage Products And Safety
For most kids, some research indicates that melatonin is healthy. Scientists are also skeptical about the consequences of long-term usage, however.
To promote sleep and regulate the internal body clock, the body naturally produces melatonin at night.
To help with sleep issues, some individuals take a synthetic form. Synthetic melatonin is classified by the United States as a dietary supplement, rather than a drug.
We discuss the latest studies on the safety of melatonin and the most appropriate dosages for children in this article. We also mention some of the gummy and liquid melatonin products for children that are best tested.
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What Is The Proper Melatonin Dosage For Adults
If youre considering taking a supplement, you might be asking yourself, How much melatonin should I take? Or you might wonder how much melatonin someone should take for the desired effectis less more? How much melatonin is too much?
The safe amount of melatonin that can be taken ranges in doses of 0.310 mg per day, but it really depends on your age and specific sleep issue. Typically, its best to start with a low dose and increase it to find what works best for you.6 If you aim to improve sleep quality, take melatonin about 30-60 minutes before you go to bed for maximum effectiveness. If you feel groggy the next day after using melatonin as a natural sleep aid, you may have taken too high of a dosage. If this happens, try taking a lower dose next time and see if that solves the problem.4
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What Are Signs Of A Melatonin Overdose
If you deal with insomnia, you might do anything for relief. Melatonin is a popular go-to sleep aid because its natural and has a low risk of unwanted side effects.
But while side effects are less common with melatonin compared with other sleep aids, you may experience a few if you overdose and take too much.
There dont appear to be any reports of people dying from overuse of melatonin. But while overuse might not cause death, it can cause a few of the below symptoms:
- Headache
Theres also the threat of rebound insomnia when theres too much of the hormone in your system. Melatonin may stop working after a while, and your sleep problems could even worsen.
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Is Melatonin Safe Forchildren
Its no wonder parents are uncertain about this. If you surfthe web, youre likely to get mixed messages:
- Australian experts called the increase in use among children alarming and warned in 2015 that parents shouldnt give it to their children. WebMD
- Melatonin, according to more than 24 studies, is safe for children and has been used with little to no side effects. NaturalSleep.org
- Currently, we dont have any evidence to say that taking melatonin on a daily basis in that sense is harmful, although there are no large-scale multicenter clinical trials to really test that.Medscape
This last quote is probably closest to where we actuallyare. However, it is clear there has been a dramatic increase in use ofmelatonin in children in the past five years or so. For example, in England, estimates have found a 25percent increase in melatonin prescriptions in children under 18 between2015-16 and 2017-18, and a 40 percent increase in the extended release formsduring the same period. There are no similar statistics in the U.S. forover-the-counter melatonin, but it is now rare in our experience that childrencoming to the Boston Childrens Sleep Clinic with insomnia are not already onmelatonin, usually recommended by their pediatrician.
What Are The Health Benefits Of Taking Melatonin
Melatonin supplements may help with certain conditions, such as jet lag, delayed sleep-wake phase disorder, some sleep disorders in children, and anxiety before and after surgery.
Jet lag
Jet lag affects people when they travel by air across multiple time zones. With jet lag, you may not feel well overall and you may have disturbed sleep, daytime tiredness, impaired functioning, and digestive problems.
Research suggests that melatonin supplements may help with jet lag. This is based on medium-sized reviews from 2010 and 2014.
- Four studies that included a total of 142 travelers showed that melatonin may be better than a placebo in reducing overall symptoms of jet lag after eastward flights. Another study of 234 travelers on eastward flights looked at only sleep quality and found low-quality evidence that melatonin may be better than placebo for improving sleep quality.
- Two studies that included a total of 90 travelers showed that melatonin may be better than a placebo in reducing symptoms of jet lag after westward flights.
Delayed sleep-wake phase disorder
People with DSWPD have trouble falling asleep at the usual times and waking up in the morning. They typically have difficulty getting to sleep before 2 to 6 a.m. and would prefer to wake up between 10 a.m. and 1 p.m.
Some sleep disorders in children
Because of these uncertainties, itâs best to work with a health care provider if youâre considering giving a child melatonin for sleep problems.
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